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  1. No Access

    Article

    High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in develo** rats

    Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are p...

    Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I. Shimizu… in Metabolic Brain Disease (2017)

  2. No Access

    Article

    Postnatal interleukin-1β administration after experimental prolonged febrile seizures enhances epileptogenesis in adulthood

    It remains unclear whether prolonged febrile seizures (pFS) in childhood facilitate mesial temporal lobe epilepsy (MTLE) in adulthood. Interleukin (IL)-1β is associated with seizures in children and immature a...

    Mitsumasa Fukuda, Masanori Ito, Yoshiaki Yano, Hisaaki Takahashi… in Metabolic Brain Disease (2015)

  3. No Access

    Article

    Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma

    Accumulating evidence shows that the expression level of Oct-3/4, a self-renewal regulator in stem cells, is positively correlated with the progression of various solid tumors. However, little is known regardi...

    Hisaaki Takahashi, Akihiro Inoue, Yuya Kawabe, Yuki Hosokawa… in Brain Tumor Pathology (2015)

  4. No Access

    Article

    Postnatal interleukin-1β enhances adulthood seizure susceptibility and neuronal cell death after prolonged experimental febrile seizures in infantile rats

    Febrile seizures (FS) are recognized as an antecedent to the development of temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), but it is unclear whether prolonged FS are a direct cause of TLE-HS. Here...

    Mitsumasa Fukuda, Hitomi Hino, Yuka Suzuki, Hisaaki Takahashi… in Acta Neurologica Belgica (2014)

  5. No Access

    Article

    Region-specific neuron and synapse loss in the hippocampus of APPSL/PS1 knock-in mice

    Transgenic mouse models with knock-in (KI) expression of human mutant amyloid precursor protein (APP) and/or human presenilin 1 (PS1) may be helpful to elucidate the cellular consequences of APP and PS1 mispro...

    Ivona Brasnjevic, Roy Lardenoije, Christoph Schmitz… in Translational Neuroscience (2013)

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    Article

    Hippocampal interneuron loss in an APP/PS1 double mutant mouse and in Alzheimer’s disease

    Hippocampal atrophy and neuron loss are commonly found in Alzheimer’s disease (AD). However, the underlying molecular mechanisms and the fate in the AD hippocampus of subpopulations of interneurons that expres...

    Hisaaki Takahashi, Ivona Brasnjevic, Bart P. F. Rutten… in Brain Structure and Function (2010)

  7. Article

    Open Access

    Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice

    Although nutrients, including amino acids and their metabolites such as serotonin (5-HT), are strong modulators of anxiety-related behavior, the metabolic pathway(s) responsible for this physiological modulati...

    Masaaki Kanai, Hiroshi Funakoshi, Hisaaki Takahashi, Tomoko Hayakawa… in Molecular Brain (2009)

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