25 Result(s)
-
Article
Open AccessNon-invasive chronic kidney disease risk stratification tool derived from retina-based deep learning and clinical factors
Despite the importance of preventing chronic kidney disease (CKD), predicting high-risk patients who require active intervention is challenging, especially in people with preserved kidney function. In this stu...
-
Article
Open AccessValidation of a deep-learning-based retinal biomarker (Reti-CVD) in the prediction of cardiovascular disease: data from UK Biobank
Currently in the United Kingdom, cardiovascular disease (CVD) risk assessment is based on the QRISK3 score, in which 10% 10-year CVD risk indicates clinical intervention. However, this benchmark has limited ef...
-
Article
Open AccessMelatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
Doxorubicin is one of the most effective agents used to treat various cancers, including breast cancer, but its usage is limited by the risk of adverse effects, including cardiotoxicity. Melatonin, a natural h...
-
Article
Open AccessPrognostic value of noggin protein expression in patients with resected gastric cancer
Noggin and RNA-binding protein for multiple splicing 2 (RBPMS2) are known to regulate the expression of smooth muscle cells, endothelial cells, and osteoblasts. However, the prognostic role of combined Noggin ...
-
Article
Open AccessMelatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
The clinical application of doxorubicin, one of the most effective anticancer drugs, has been limited due to its adverse effects, including cardiotoxicity. One of the hallmarks of doxorubicin-induced cytotoxic...
-
Article
Open AccessDevelopment of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis
MicroRNAs (miRNAs) are considered to be strong prognostic markers and key therapeutic targets in human diseases, especially cancer. A sensitive monitoring platform for cancer-associated miRNA (oncomiR) action ...
-
Article
Open AccessCombination of Helicobacter pylori infection and the interleukin 8 –251 T > A polymorphism, but not the mannose-binding lectin 2 codon 54 G > A polymorphism, might be a risk factor of gastric cancer
Mannose-binding lectin (MBL) acts in the innate immune response to Helicobacter pylori. Interleukin 8 (IL-8) is a potent cytokine produced by gastric epithelial cells in response to H. pylori. We aimed to investi...
-
Article
Open AccessTherapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis
Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated the use of genetically engineered MSCs that overexpress hepat...
-
Article
Open AccessSimultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) promoter limits expressio...
-
Article
Open AccessCancer cell metabolism: implications for therapeutic targets
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked...
-
Article
Open AccessMitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with antioxidant and anti-apoptotic functions. Reactive oxygen species are involved in many inflammatory diseases including inflammato...
-
Article
Open AccessRetrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability to migrate...
-
Article
Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype
Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equo...
-
Article
Open AccessMacronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food products has...
-
Article
Open AccessThe function of p27KIP1 during tumor development
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitor...
-
Article
Open AccessMesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Mesenchymal stem cells (MSCs) secrete bioactive factors that exert diverse responses in vivo. In the present study, we explored mechanism how MSCs may lead to higher functional recovery in the animal stroke model...
-
Article
Open AccessCyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kin...
-
Article
Open AccessResveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive propertie...
-
Article
Open AccessForskolin promotes astroglial differentiation of human central neurocytoma cells
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation of neurocytoma cel...
-
Article
Pott's paraplegia in patients with severely deformed dorsal or dorsolumbar spines: treatment and prognosis
Study design: Pott's paraplegic patients with severe spinal deformity were reviewed retrospectively after being treated with chemotherapy and/or decompressive surgery.
