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  1. No Access

    Article

    High levels of luteinizing hormone analog stimulate gonadal and adrenal tumorigenesis in mice transgenic for the mouse inhibin-α-subunit promoter/Simian virus 40 T-antigen fusion gene

    Transgenic (TG) mice expressing the Simian virus 40 T-antigen under the control of the murine inhibin-α promoter (Inhα/Tag) develop granulosa and Leydig cell tumors at the age of 5–6 months, with 100% penetrance....

    Maarit Mikola, Jukka Kero, John H Nilson, Ruth A Keri, Matti Poutanen… in Oncogene (2003)

  2. No Access

    Article

    Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-β signaling in ErbB2/Neu-induced tumors from transgenic mice

    Upregulation of HER2/ErbB2/Neu occurs in 15–30% of human breast cancers and correlates with poor prognosis. Identification of ErbB2/Neu transcriptional targets should facilitate development of novel therapeuti...

    Melissa D Landis, Darcie D Seachrist, Marjorie E Montañez-Wiscovich… in Oncogene (2005)

  3. Article

    Open Access

    Intrinsic bias in breast cancer gene expression data sets

    While global breast cancer gene expression data sets have considerable commonality in terms of their data content, the populations that they represent and the data collection methods utilized can be quite disp...

    Jonathan D Mosley, Ruth A Keri in BMC Cancer (2009)

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  4. No Access

    Article

    Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors

    Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7 expression and MMP7 ...

    Steven T. Sizemore, Gina M. Sizemore… in Breast Cancer Research and Treatment (2014)

  5. Article

    Open Access

    Follistatin is a metastasis suppressor in a mouse model of HER2-positive breast cancer

    Follistatin (FST) is an intrinsic inhibitor of activin, a member of the transforming growth factor-β superfamily of ligands. The prognostic value of FST and its family members, the follistatin-like (FSTL) prot...

    Darcie D. Seachrist, Steven T. Sizemore, Emhonta Johnson… in Breast Cancer Research (2017)

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  6. No Access

    Article

    Expression of LC3B and FIP200/Atg17 in brain metastases of breast cancer

    Macroautophagy/autophagy is considered to play key roles in tumor cell evasion of therapy and establishment of metastases in breast cancer. High expression of LC3, a residual autophagy marker, in primary breas...

    Nooshin Hashemi-Sadraei, Gaëlle M. Müller-Greven… in Journal of Neuro-Oncology (2018)

  7. Article

    Open Access

    KLF4 defines the efficacy of the epidermal growth factor receptor inhibitor, erlotinib, in triple-negative breast cancer cells by repressing the EGFR gene

    Triple-negative breast cancer (TNBC) is characterized by high rates of recurrence and poor overall survival. This is due, in part, to a deficiency of targeted therapies, making it essential to identify therape...

    Melyssa S. Roberts, Lindsey J. Anstine, Viviane S. Finke… in Breast Cancer Research (2020)

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