37 Result(s)

Article

Revisiting STAT3 signalling in cancer: new and unexpected biological functions

Article

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

Physiological Stat3 signaling is temporally restricted. In cancer, Stat3 activity is often persistently elevated and fosters progression through its effects on tumor cells and their microenvironment. This repo...

Heehyoung Lee, Jiehui Deng, Maciej Kujawski, Chunmei Yang, Yong Liu… in Nature Medicine (2010)

Article

STATs in cancer inflammation and immunity: a leading role for STAT3

Article

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

Tumors generate microenvironments that actively suppress the body's anti-tumor immune response. Kortylewski et al. restore immunity by delivering an siRNA against Stat3, a regulator of immune suppression, to myel...

Marcin Kortylewski, Piotr Swiderski, Andreas Herrmann, Lin Wang… in Nature Biotechnology (2009)

Article

Signal Transduction Proteins in Tumors From Puerto Rican and Caucasian Gastric Adenocarcinoma Patients: Expression Differences With Potential for Specific Targeted Therapies

Overexpression of the HER2/NEU gene is associated with aggressive behavior and poor prognosis in breast cancer, making the Her2/neu protein a directed-therapy target. Tumors of two Puerto Rican (PR) patients over...

José Cangiano, Barbara A. Centeno… in Digestive Diseases and Sciences (2008)

Article

Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

The immune system can act as an extrinsic suppressor of tumors. Therefore, tumor progression depends in part on mechanisms that downmodulate intrinsic immune surveillance. Identifying these inhibitory pathways...

Marcin Kortylewski, Maciej Kujawski, Tianhong Wang, Sheng Wei… in Nature Medicine (2005)

Article

Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways

Vascular endothelial growth factor (VEGF) upregulation is induced by many receptor and intracellular oncogenic proteins commonly activated in cancer, rendering molecular targeting of VEGF expression a complex ...

Qing Xu, Jon Briggs, Sungman Park, Guilian Niu, Marcin Kortylewski… in Oncogene (2005)

Article

Targeting STAT3 affects melanoma on multiple fronts

As a point of convergence for numerous oncogenic signaling pathways, STAT3 is constitutively-activated at 50 to 90% frequency in diverse human cancers, including melanoma. A critical role of STAT3 in tumor cel...

Marcin Kortylewski, Richard Jove, Hua Yu in Cancer and Metastasis Reviews (2005)

Article

Mechanisms of Disease: insights into the emerging role of signal transducers and activators of transcription in cancer

Members of the signal transducers and activators of transcription (STAT) pathway have recently been demonstrated to have a major role in cancer. Constitutive activation of the STAT family members Stat3 and Sta...

Eric B Haura, James Turkson, Richard Jove in Nature Clinical Practice Oncology (2005)

Article

Stat3 regulates genes common to both wound healing and cancer

Wound healing and cancer are both characterized by cell proliferation, remodeling of extracellular matrix, cell invasion and migration, new blood vessel formation, and modulation of blood coagulation. The mech...

Daniel J Dauer, Bernadette Ferraro, Lanxi Song, Bin Yu, Linda Mora… in Oncogene (2005)

Article

Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity

Constitutive activation of the JAK/STAT3 pathway is a major contributor to oncogenesis. In the present study, structure–activity relationship (SAR) studies with five cucurbitacin (Cuc) analogs, A, B, E, I, and...

Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston… in Oncogene (2005)

Article

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells

Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic...

Adina Vultur, Jun Cao, Rozanne Arulanandam, James Turkson, Richard Jove… in Oncogene (2004)

Article

The STATs of cancer — new molecular targets come of age

Article

Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

Although tumor progression involves processes such as tissue invasion that can activate inflammatory responses, the immune system largely ignores or tolerates disseminated cancers. The mechanisms that block in...

Tianhong Wang, Guilian Niu, Marcin Kortylewski, Lyudmila Burdelya… in Nature Medicine (2004)

Article

Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells

Overexpression of receptor tyrosine kinases including the epidermal growth factor receptor (EGF-R) as well as nonreceptor tyrosine kinases, such as Src, have been implicated in the formation of human lung canc...

Lanxi Song, James Turkson, James G Karras, Richard Jove, Eric B Haura in Oncogene (2003)

Article

Inhibition of Bcr–Abl kinase activity by PD180970 blocks constitutive activation of Stat5 and growth of CML cells

Chronic myelogenous leukemia (CML) is a myeloproliferative disease characterized by the BCR–ABL genetic translocation and constitutive activation of the Abl tyrosine kinase. Among members of the Signal Transdu...

Mei Huang, Jay F Dorsey, PK Epling-Burnette, Ramadevi Nimmanapalli… in Oncogene (2002)

Article

Roles of activated Src and Stat3 signaling in melanoma tumor cell growth

Activation of protein tyrosine kinases is prevalent in human cancers and previous studies have demonstrated that Stat3 signaling is a point of convergence for many of these tyrosine kinases. Moreover, a critic...

Guilian Niu, Tammy Bowman, Mei Huang, Steve Shivers, Douglas Reintgen… in Oncogene (2002)