818 Result(s)
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Article
A 13,000-year climate record from western Tibet
ALTHOUGH the Tibetan plateau is important in influencing the atmospheric circulation of the Northern Hemisphere1–3, there are only a few continuous palaeoclimate records available, and these are limited to the p...
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Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Ventricular fibrillation causes more than 300, 000 sudden deaths each year in the USA alone1,2. In approximately 5–12% of these cases, there are no demonstrable cardiac or non-cardiac causes to account for the ep...
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Recycling lower continental crust in the North China craton
Foundering of mafic lower continental crust into underlying convecting mantle has been proposed as one means to explain the unusually evolved chemical composition of Earth's continental crust1,2, yet direct evide...
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An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection
Gene silencing by small interfering RNAs (siRNAs) is involved in many biological processes. It has the potential to become an important form of therapy, but a major obstacle is the difficulty of delivering siR...
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Medium-scale carbon nanotube thin-film integrated circuits on flexible plastic substrates
Integrated circuits formed on flexible plastic sheets can be lighter and tougher than those made from conventional materials, as well as being usefully bendy. Semiconductors made from organic small molecules a...
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iPS cells produce viable mice through tetraploid complementation
Since iPS (induced pluripotent stem) cells arrived on the scene in 2006, their properties have been measured against the yardstick of the true embryonic stem cells that they mimic. A clutch of recent papers, t...
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Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
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Re-emerging superconductivity at 48 kelvin in iron chalcogenides
Unexpectedly, in superconducting iron chalcogenides, a second, much higher, maximum in the superconducting transition temperature emerges under increasing pressure.
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Electronic origin of high-temperature superconductivity in single-layer FeSe superconductor
The recent discovery of high-temperature superconductivity in iron-based compounds has attracted much attention. How to further increase the superconducting transition temperature (Tc) and how to understand the s...
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Open AccessAkt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila
Gold nanoparticles (AuNPs) are often used as vehicles to deliver drugs or biomolecules, due to their mild effect on cell survival and proliferation. However, little is known about their effect on cellular meta...
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Open AccessNitrogen-doped graphene: beyond single substitution and enhanced molecular sensing
Graphene is a two-dimensional network in which sp2-hybridized carbon atoms are arranged in two different triangular sub-lattices (A and B). By incorporating nitrogen atoms into graphene, its physico-chemical prop...
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Open AccessPd/C Synthesized with Citric Acid: An Efficient Catalyst for Hydrogen Generation from Formic Acid/Sodium Formate
A highly efficient hydrogen generation from formic acid/sodium formate aqueous solution catalyzed by in situ synthesized Pd/C with citric acid has been successfully achieved at room temperature. Interestingly, th...
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Article
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed exome sequencing and copy number analysis to define genomic aberrations in a prospectively accrued clinical cohort (n = 1...
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Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing
5-methylcytosine is an epigenetic mark that affects a broad range of biological functions in mammals. The chemically inert methyl group prevents direct labelling for subsequent affinity purification and detect...
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Open AccessDraft genome of the wheat A-genome progenitor Triticum urartu
The genome sequence and its analysis of the diploid wild wheat Triticum urartu (progenitor of the wheat A genome) represent a tool for studying the complex, polyploid wheat genomes and should be a valuable resour...
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Metallized DNA nanolithography for encoding and transferring spatial information for graphene patterning
The vision for graphene and other two-dimensional electronics is the direct production of nanoelectronic circuits and barrier materials from a single precursor sheet. DNA origami and single-stranded tiles are ...
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Open AccessA simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds
We describe a simple method for bone engineering using biodegradable scaffolds with mesenchymal stem cells derived from human induced-pluripotent stem cells (hiPS-MSCs). The hiPS-MSCs expressed mesenchymal mar...
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Open AccessNonlinear Growth Kinetics of Breast Cancer Stem Cells: Implications for Cancer Stem Cell Targeted Therapy
Cancer stem cells (CSCs) have been identified in primary breast cancer tissues and cell lines. The CSC population varies widely among cancerous tissues and cell lines and is often associated with aggressive br...
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Open AccessDiscovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity. The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl-tRNA synthetase (LeuRS) plays an...
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Open AccessA novel molecular index for secondary oil migration distance
Determining oil migration distances from source rocks to reservoirs can greatly help in the search for new petroleum accumulations. Concentrations and ratios of polar organic compounds are known to change due ...
