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Danger in plain sight: determining who is at highest risk for cefepime induced neurotoxicity and its associated morbidity and mortality
Cefepime is a fourth-generation cephalosporin that is widely used to treat sepsis but is associated with a potentially dangerous neurotoxicity syndrome, cefepime-induced neurotoxicity (CIN). As a result, patie...
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Open AccessDetermining ICU EEG periodic patterns and why it matters
Historically, periodic EEG patterns were described as any pattern with stereotyped paroxysmal complexes occurring at regular intervals, i.e., the period (T). T is the sum of the duration of the waveform (t1) and,...
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Open AccessNonconvulsive status epilepticus following cardiac arrest: overlooked, untreated and misjudged
Seizures and status epilepticus (SE) are detected in almost a third of the comatose cardiac arrest survivors. As the literature is quite exhaustive regarding SE with motor symptoms in those patients, little is...
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Transnasal Revolution? The Promise of Midazolam Spray to Prevent Seizure Clusters
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Open AccessUpdated nomenclature of delirium and acute encephalopathy: statement of ten Societies
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Open AccessAdmission EEG findings in diverse paediatric cerebral malaria populations predict outcomes
Electroencephalography at hospital presentation may offer important insights regarding prognosis that can inform understanding of cerebral malaria (CM) pathophysiology and potentially guide patient selection a...
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Anesthetics and Outcome in Status Epilepticus: A Matched Two-Center Cohort Study
The use of anesthetics has been linked to poor outcome in patients with status epilepticus (SE). This association, however, may be confounded, as anesthetics are mostly administered in patients with more sever...
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Nonconvulsive status epilepticus in adults — insights into the invisible
Nonconvulsive status epilepticus (NCSE) is defined as a continuous state of seizures without convulsions, or multiple nonconvulsive seizures for more than 30 m...
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Significance of Parenchymal Brain Damage in Patients with Critical Illness
To determine the prevalence, type, and significance of brain damage in critically ill patients with a primary non-neurological diagnosis develo** acute brain dysfunction.
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Outcome predictors for status epilepticus—what really counts
Determination of prognosis in patients with status epilepticus (SE)—a life-threatening state of ongoing or repetitive seizures—is difficult, and current outcome prediction scales do not take into account novel...
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Calculating the Risk Benefit Equation for Aggressive Treatment of Non-convulsive Status Epilepticus
To address the question: does non-convulsive status epilepticus warrant the same aggressive treatment as convulsive status epilepticus?
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Clinical and imaging correlates of EEG patterns in hospitalized patients with encephalopathy
To identify the relationship between pathologic electroencephalographic (EEG) patterns, clinical and neuroradiological abnormalities, and outcome in hospitalized patients with acute encephalopathy. This 5-year...
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Ambulatory non-convulsive status epilepticus evolving into a malignant form
We retrospectively analysed the clinical characteristics, electroencephalogram (EEG) records, brain magnetic resonance imaging (MRI) scans, antiepileptic therapy and prognosis of a case series with ambulatory ...
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The effect of therapeutic hypothermia on prognostication
Neurological markers are used to predict outcomes in patients resuscitated after cardiac arrest, and are crucial in informing treatment decisions in comatose patients. A multicenter study reports that therapeu...
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Confusion and SIRPIDs regress with parenteral lorazepam
Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) are EEG epileptiform periodic discharges (PD) induced by arousal. SIRPIDs lie along an ictal-interictal continuum with debate regarding urgency...
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Tonic status and electrodecremental paroxysms in an adult without epilepsy
Electrodecremental status epilepticus is classically described in infants and children with severe refractory epilepsy, mental retardation, and structural brain abnormalities. We describe a 24-year-old woman w...
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Open AccessPrognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest
Continuous EEG (cEEG) is increasingly used to monitor brain function in neuro-ICU patients. However, its value in patients with coma after cardiac arrest (CA), particularly in the setting of therapeutic hypoth...