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  1. No Access

    Article

    Danger in plain sight: determining who is at highest risk for cefepime induced neurotoxicity and its associated morbidity and mortality

    Cefepime is a fourth-generation cephalosporin that is widely used to treat sepsis but is associated with a potentially dangerous neurotoxicity syndrome, cefepime-induced neurotoxicity (CIN). As a result, patie...

    Brin E. Freund, Khalil S. Husari, Peter W. Kaplan in Acta Neurologica Belgica (2024)

  2. Article

    Open Access

    Determining ICU EEG periodic patterns and why it matters

    Historically, periodic EEG patterns were described as any pattern with stereotyped paroxysmal complexes occurring at regular intervals, i.e., the period (T). T is the sum of the duration of the waveform (t1) and,...

    Philippe Gélisse, William O. Tatum, Arielle Crespel, Pierre Jallon in Journal of Neurology (2023)

  3. Article

    Open Access

    Nonconvulsive status epilepticus following cardiac arrest: overlooked, untreated and misjudged

    Seizures and status epilepticus (SE) are detected in almost a third of the comatose cardiac arrest survivors. As the literature is quite exhaustive regarding SE with motor symptoms in those patients, little is...

    Pia De Stefano, Peter W. Kaplan, Hervé Quintard, Margitta Seeck in Journal of Neurology (2023)

  4. No Access

    Article

    Transnasal Revolution? The Promise of Midazolam Spray to Prevent Seizure Clusters

    Raoul Sutter, Peter W. Kaplan in CNS Drugs (2020)

  5. Article

    Open Access

    Updated nomenclature of delirium and acute encephalopathy: statement of ten Societies

    Arjen J. C. Slooter, Wim M. Otte, John W. Devlin in Intensive Care Medicine (2020)

  6. Article

    Open Access

    Admission EEG findings in diverse paediatric cerebral malaria populations predict outcomes

    Electroencephalography at hospital presentation may offer important insights regarding prognosis that can inform understanding of cerebral malaria (CM) pathophysiology and potentially guide patient selection a...

    Douglas G. Postels, **aoting Wu, Chenxi Li, Peter W. Kaplan in Malaria Journal (2018)

  7. Article

    Anesthetics and Outcome in Status Epilepticus: A Matched Two-Center Cohort Study

    The use of anesthetics has been linked to poor outcome in patients with status epilepticus (SE). This association, however, may be confounded, as anesthetics are mostly administered in patients with more sever...

    Raoul Sutter, Gian Marco De Marchis, Saskia Semmlack, Peter Fuhr in CNS Drugs (2017)

  8. No Access

    Article

    Nonconvulsive status epilepticus in adults — insights into the invisible

  9. Nonconvulsive status epilepticus (NCSE) is defined as a continuous state of seizures without convulsions, or multiple nonconvulsive seizures for more than 30 m...

  10. Raoul Sutter, Saskia Semmlack, Peter W. Kaplan in Nature Reviews Neurology (2016)

  11. No Access

    Article

    Significance of Parenchymal Brain Damage in Patients with Critical Illness

    To determine the prevalence, type, and significance of brain damage in critically ill patients with a primary non-neurological diagnosis develo** acute brain dysfunction.

    Raoul Sutter, Julio A. Chalela, Richard Leigh, Peter W. Kaplan in Neurocritical Care (2015)

  12. No Access

    Article

    Outcome predictors for status epilepticus—what really counts

    Determination of prognosis in patients with status epilepticus (SE)—a life-threatening state of ongoing or repetitive seizures—is difficult, and current outcome prediction scales do not take into account novel...

    Raoul Sutter, Peter W. Kaplan, Stephan Rüegg in Nature Reviews Neurology (2013)

  13. Article

    Calculating the Risk Benefit Equation for Aggressive Treatment of Non-convulsive Status Epilepticus

    To address the question: does non-convulsive status epilepticus warrant the same aggressive treatment as convulsive status epilepticus?

    Matthew Ferguson, Matt T. Bianchi, Raoul Sutter, Eric S. Rosenthal in Neurocritical Care (2013)

  14. Article

    Clinical and imaging correlates of EEG patterns in hospitalized patients with encephalopathy

    To identify the relationship between pathologic electroencephalographic (EEG) patterns, clinical and neuroradiological abnormalities, and outcome in hospitalized patients with acute encephalopathy. This 5-year...

    Raoul Sutter, Robert D. Stevens, Peter W. Kaplan in Journal of Neurology (2013)

  15. Article

    Ambulatory non-convulsive status epilepticus evolving into a malignant form

    We retrospectively analysed the clinical characteristics, electroencephalogram (EEG) records, brain magnetic resonance imaging (MRI) scans, antiepileptic therapy and prognosis of a case series with ambulatory ...

    José L. Fernández-Torre, Peter W. Kaplan, Mariano Rebollo in Epileptic Disorders (2012)

  16. No Access

    Article

    The effect of therapeutic hypothermia on prognostication

    Neurological markers are used to predict outcomes in patients resuscitated after cardiac arrest, and are crucial in informing treatment decisions in comatose patients. A multicenter study reports that therapeu...

    Romergryko G. Geocadin, Peter W. Kaplan in Nature Reviews Neurology (2012)

  17. Article

    Confusion and SIRPIDs regress with parenteral lorazepam

    Stimulus-induced rhythmic, periodic or ictal discharges (SIRPIDs) are EEG epileptiform periodic discharges (PD) induced by arousal. SIRPIDs lie along an ictal-interictal continuum with debate regarding urgency...

    Peter W. Kaplan, Josh Duckworth in Epileptic Disorders (2011)

  18. Article

    Tonic status and electrodecremental paroxysms in an adult without epilepsy

    Electrodecremental status epilepticus is classically described in infants and children with severe refractory epilepsy, mental retardation, and structural brain abnormalities. We describe a 24-year-old woman w...

    Lyle W. Ostrow, Peter W. Kaplan in Epileptic Disorders (2011)

  19. Article

    Open Access

    Prognostic value of continuous EEG monitoring during therapeutic hypothermia after cardiac arrest

    Continuous EEG (cEEG) is increasingly used to monitor brain function in neuro-ICU patients. However, its value in patients with coma after cardiac arrest (CA), particularly in the setting of therapeutic hypoth...

    Andrea O Rossetti, Luis A Urbano, Frederik Delodder, Peter W Kaplan in Critical Care (2010)