Sleep Deprivation and Disease
Effects on the Body, Brain and Behavior
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Open AccessSleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study
Insufficient sleep duration and obstructive sleep apnea, two common causes of sleep deficiency in adults, can result in excessive sleepiness, a well-recognized cause of motor vehicle crashes, although their co...
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Open AccessADARRI: a novel method to detect spurious R-peaks in the electrocardiogram for heart rate variability analysis in the intensive care unit
We developed a simple and fully automated method for detecting artifacts in the R-R interval (RRI) time series of the ECG that is tailored to the intensive care unit (ICU) setting. From ECG recordings of 50 ad...
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Interactions of time of day and sleep with between-session habituation and extinction memory in young adult males
Within-session habituation and extinction learning co-occur as do subsequent consolidation of habituation (i.e., between-session habituation) and extinction memory. We sought to determine whether, as we predicte...
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A Novel Home Sleep Monitoring Device and Brief Sleep Intervention for Bipolar Disorder: Feasibility, Tolerability, and Preliminary Effectiveness
Sleep disturbance is common in bipolar disorder and negatively impacts its course of illness. The purpose of this study is to assess the feasibility and tolerability of a novel EKG-based home sleep monitoring ...
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Calculating the Risk Benefit Equation for Aggressive Treatment of Non-convulsive Status Epilepticus
To address the question: does non-convulsive status epilepticus warrant the same aggressive treatment as convulsive status epilepticus?
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Mammalian sleep genetics
Mammalian sleep is a complex phenomenon governed by the interplay of neural circuits and signaling systems. The impact of genetic manipulations on sleep–wake dynamics provides important insights into this comp...
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Open AccessSignificance testing as perverse probabilistic reasoning
Truth claims in the medical literature rely heavily on statistical significance testing. Unfortunately, most physicians misunderstand the underlying probabilistic logic of significance tests and consequently o...
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Aggressive Care After a Massive Stroke in Young Patients: Is That What They Want?
The assumption is often made that aggressive care in the form of early decompressive hemicraniectomy is appropriate for young patients who suffer a massive stroke. However, neither their attitude toward aggres...
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Open AccessTargeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity?
The traditional emphasis on develo** high specificity pharmaceuticals ("magic bullets") for the treatment of Neurological and Psychiatric disorders is being challenged by emerging pathophysiology concepts th...
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Functional characterization of the new human GABAA receptor mutation β3(R192H)
We screened 124 individuals for single nucleotide polymorphisms of the α1, β3 and γ2 genes of the GABAA receptor in the regions corresponding to the ligand-binding domains on the protein level. In a patient with...
