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Structural changes in the mitochondrial Tim23 channel are coupled to the proton-motive force
The mitochondrial inner membrane generates a proton-motive force (PMF) that drives cellular processes. Using a high-resolution fluorescence map** approach combined with kinetic analyses, changes in the PMF a...
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Article
Open AccessAllosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state
PPM1D encodes a serine/threonine phosphatase that regulates numerous pathways including the DNA damage response and p53. Activating mutations and amplification of PPM1D are found across numerous cancer types. GSK...