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  1. Article

    Open Access

    Smaller stencil preconditioners for linear systems in RBF-FD discretizations

    Radial basis function finite difference (RBF-FD) discretization has recently emerged as an alternative to classical finite difference or finite element discretization of (systems) of partial differential equat...

    Michael Koch, Sabine Le Borne, Willi Leinen in Numerical Algorithms (2024)

  2. Article

    Open Access

    Local Administrations of Iron Oxide Nanoparticles in the Prefrontal Cortex and Caudate Putamen of Rats Do Not Compromise Working Memory and Motor Activity

    Iron oxide nanoparticles (IONPs) have come into focus for their use in medical applications although possible health risks for humans, especially in terms of brain functions, have not yet been fully clarified....

    Ellen Irrsack, Sidar Aydin, Katja Bleckmann, Julia Schuller in Neurotoxicity Research (2023)

  3. No Access

    Article

    Sonographie des Halses – differenzialdiagnostische Aspekte

    Die Sonographie stellt die bevorzugte Methode für die Primärdiagnose und die Akutversorgung bei Pathologien im Bereich der Halsweichteile dar. Technologische Fortschritte, insbesondere eine hohe Bildauflösung ...

    PD Dr. med. Matti Sievert, Michael Koch, Heinrich Iro, Vivian Thimsen in HNO (2023)

  4. Article

    Open Access

    Ultrasound in the diagnosis and differential diagnosis of enoral and plunging ranula: a detailed and comparative analysis

    To develop sonographic criteria for ranula that to allow rapid and precise diagnosis, differentiation between enoral (ER) and plunging ranula (PR), and differential diagnosis from other competing pathologies i...

    Michael Koch, Konstantinos Mantsopoulos, Victoria Leibl in Journal of Ultrasound (2023)

  5. Article

    Open Access

    Validity of tissue homogeneity in confocal laser endomicroscopy on the diagnosis of laryngeal and hypopharyngeal squamous cell carcinoma

    Confocal laser endomicroscopy (CLE) allows imaging of the laryngeal mucosa in a thousand-fold magnification. This study analyzes differences in tissue homogeneity between healthy mucosa and squamous cell carci...

    Matti Sievert, Marc Aubreville in European Archives of Oto-Rhino-Laryngology (2022)

  6. Article

    Open Access

    Genome wide association study of frost tolerance in wheat

    Winter wheat growing areas in the Northern hemisphere are regularly exposed to heavy frost. Due to the negative impact on yield, the identification of genetic factors controlling frost tolerance (FroT) and dev...

    Behnaz Soleimani, Heike Lehnert, Steve Babben, Jens Keilwagen in Scientific Reports (2022)

  7. Article

    Open Access

    Salvage-Laryngektomie nach primärer Radio- und Radiochemotherapie

    Das rezidivierende und residuelle Larynxkarzinom nach organerhaltender Radio- bzw. Radiochemotherapie ist mit einer schlechten Prognose verbunden. Die Salvage-Operation stellt in diesen Fällen die wichtigste t...

    Dr. med. Matti Sievert, Miguel Goncalves, Benedicta Binder, Sarina K. Mueller in HNO (2022)

  8. Article

    Open Access

    Effects of Local Administration of Iron Oxide Nanoparticles in the Prefrontal Cortex, Striatum, and Hippocampus of Rats

    Iron oxide nanoparticles (IONPs) are used for diverse medical approaches, although the potential health risks, for example adverse effects on brain functions, are not fully clarified. Several in vitro studies ...

    Ellen Irrsack, Julia Schuller, Charlotte Petters, Wiebke Willmann in Neurotoxicity Research (2021)

  9. Article

    Open Access

    Operationalizing the Benefit of Information Radiators from an Awareness Point of View

    In this paper, we present a grounded theory research for the benefit information radiators provided using the concept of awareness. Information radiators are ubiquitous installations that disseminate informati...

    Stefan Lippert, Michael Koch in SN Computer Science (2021)

  10. No Access

    Article

    ADEO: the European commercial passive de-orbit subsystem family enabling space debris mitigation

    The ADEO subsystem is a scalable drag augmentation device that uses the residual Earth atmosphere present in Low Earth Orbit (LEO) to passively de-orbit of satellites between 1 and 2000 kg. For the de-orbit ma...

    Daniel Stelzl, Ernst K. Pfeiffer, Hugo Garcia Hemme in CEAS Space Journal (2021)

  11. Article

    Open Access

    Erratum zu: Mensch-Computer-Interaktion als zentrales Gebiet der Informatik – Bestandsaufnahme, Trends und Herausforderungen

    Michael Koch, Jürgen Ziegler, Christian Reuter, Thomas Schlegel in Informatik Spektrum (2021)

  12. Article

    Open Access

    Salvage laryngectomy after primary radio- and radiochemotherapy

    Recurrent and residual laryngeal cancer after organ-preserving radio- or radiochemotherapy is associated with a poor prognosis. Salvage surgery is the most important therapeutic option in these cases.

    Dr. med. Matti Sievert, Miguel Goncalves, Benedicta Binder, Sarina K. Mueller in HNO (2021)

  13. Article

    Open Access

    Postoperative management of antithrombotic medication in microvascular head and neck reconstruction: a comparative analysis of unfractionated and low-molecular-weight heparin

    Free flap reconstruction is a valuable technique to preserve function in oncological head and neck surgery. Postoperative graft thrombosis is a dreaded risk. This study aims to compare low-dose unfractionated ...

    Matti Sievert, Miguel Goncalves in European Archives of Oto-Rhino-Laryngology (2021)

  14. Article

    Open Access

    Long-term live imaging and multiscale analysis identify heterogeneity and core principles of epithelial organoid morphogenesis

    Organoids are morphologically heterogeneous three-dimensional cell culture systems and serve as an ideal model for understanding the principles of collective cell behaviour in mammalian organs during developme...

    Lotta Hof, Till Moreth, Michael Koch, Tim Liebisch, Marina Kurtz in BMC Biology (2021)

  15. Article

    Open Access

    Human extrahepatic and intrahepatic cholangiocyte organoids show region-specific differentiation potential and model cystic fibrosis-related bile duct disease

    The development, homeostasis, and repair of intrahepatic and extrahepatic bile ducts are thought to involve distinct mechanisms including proliferation and maturation of cholangiocyte and progenitor cells. Thi...

    Monique M. A. Verstegen, Floris J. M. Roos, Ksenia Burka in Scientific Reports (2020)

  16. Article

    Open Access

    Mensch-Computer-Interaktion als zentrales Gebiet der Informatik – Bestandsaufnahme, Trends und Herausforderungen

    Mensch-Computer-Interaktion (MCI) beschäftigt sich mit Fragen rund um die benutzer- und kontextegerechte Gestaltung von IT-Systemen. Ohne MCI ist die vielbeschworene digitale Transformation nicht möglich, da S...

    Michael Koch, Jürgen Ziegler, Christian Reuter, Thomas Schlegel in Informatik Spektrum (2020)

  17. Article

    Open Access

    Advanced paternal age as a risk factor for neurodevelopmental disorders: a translational study

    Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia. The potential mechanisms conferring this risk are poorly understood. Here, we show tha...

    Axel Krug, Markus Wöhr, Dominik Seffer, Henrike Rippberger in Molecular Autism (2020)

  18. Article

    Incidence and relative risk of renal replacement therapy in people with and without diabetes between 2002 and 2016 in a German region

    Data on trends of end-stage renal disease among people with diabetes are lacking. We analysed the incidence of end-stage renal disease, defined as renal replacement therapy, among people with and without diabe...

    Maria Narres, Heiner Claessen, Tatjana Kvitkina, Michael Koch in Diabetologia (2020)

  19. No Access

    Article

    Outcome and management of rare high-grade “salivary” adenocarcinoma: the important role of adjuvant (chemo)radiotherapy

    To determine survival and management strategies for high-grade adenocarcinoma of salivary glands (ASG).

    Claudia Scherl, Marlen Haderlein, Abbas Agaimy in Strahlentherapie und Onkologie (2019)

  20. Article

    Open Access

    Ultra-thin fluorocarbon foils optimise multiscale imaging of three-dimensional native and optically cleared specimens

    In three-dimensional light microscopy, the heterogeneity of the optical density in a specimen ultimately limits the achievable penetration depth and hence the three-dimensional resolution. The most direct appr...

    Katharina Hötte, Michael Koch, Lotta Hof, Marcel Tuppi, Till Moreth in Scientific Reports (2019)

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