26 Result(s)
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Johan Holmberg
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Open AccessCorrection: Introducing Braining—physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method
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Open AccessIntroducing Braining—physical exercise as adjunctive therapy in psychiatric care: a retrospective cohort study of a new method
Patients with severe mental disorders suffer from higher rates of poor somatic health and have shorter life expectancy than the average population. Physical activity can treat and prevent several diseases, e.g. c...
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Open AccessPublisher Correction: HIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
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Open AccessPublisher Correction: Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
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Open AccessHIF-1 stabilization in T cells hampers the control of Mycobacterium tuberculosis infection
The hypoxia-inducible factors (HIFs) regulate the main transcriptional pathway of response to hypoxia in T cells and are negatively regulated by von Hippel-Lindau factor (VHL). But the role of HIFs in the regu...
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Open AccessImpaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome
Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcrip...
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Open AccessAuthor Correction: A comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
In the originally published version of this Article, financial support was not fully acknowledged. The PDF and HTML versions of the Article have now been corrected to include support to Thomas Perlmann provide...
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Open AccessNexilin/NEXN controls actin polymerization in smooth muscle and is regulated by myocardin family coactivators and YAP
Nexilin, encoded by the NEXN gene, is expressed in striated muscle and localizes to Z-discs, influencing mechanical stability. We examined Nexilin/NEXN in smooth muscle cells (SMCs), and addressed if Nexilin loca...
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Open AccessA comprehensive map coupling histone modifications with gene regulation in adult dopaminergic and serotonergic neurons
The brain is composed of hundreds of different neuronal subtypes, which largely retain their identity throughout the lifespan of the organism. The mechanisms governing this stability are not fully understood, ...
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Open AccessSumoylation of Notch1 represses its target gene expression during cell stress
The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes req...
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Open AccessPotent pro-inflammatory and pro-fibrotic molecules, osteopontin and galectin-3, are not major disease modulators of laminin α2 chain-deficient muscular dystrophy
A large number of human diseases are caused by chronic tissue injury with fibrosis potentially leading to organ failure. There is a need for more effective anti-fibrotic therapies. Congenital muscular dystroph...
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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Gliomas recruit and manipulate microglial function to promote their growth. Joseph and colleagues reveal the molecular basis of this manipulation by showing that gliomas trigger S-nitrosylation of microglial c...
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Process Improvements in Methanol Oxidation to Formaldehyde: Application and Catalyst Development
Compared with oxide catalysts for many other selective oxidation and ammoxidation processes, the commercial iron molybdate type catalyst for the oxidation of methanol to formaldehyde has an outstanding perform...
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Combination of many-body perturbation theory and quantum electrodynamics
A procedure for energy-dependent perturbation expansion has been developed, based upon the covariant evolution operator method. This makes it possible to treat energy-dependent perturbations very much like th...
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PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner
Activation of Notch signaling requires intracellular routing of the receptor, but the mechanisms controlling the distinct steps in the routing process is poorly understood. We identify PKCζ as a key regulator ...
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Maintaining differentiated cellular identity
Reprogramming studies have shown that somatic differentiated cells retain plasticity, but how their identities are stably maintained under normal conditions is...
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Reduced postural differences between phobic postural vertigo patients and healthy subjects during a postural threat
Phobic postural vertigo is characterized by subjective imbalance and dizziness while standing or walking, despite normal values for clinical balance tests. Patients with phobic postural vertigo exhibit an incr...
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Substituted Mo–V(Ti)–Te(Ce)-oxide M2 Catalysts for Propene Ammoxidation
One of the most effective propane to acrylonitrile ammoxidation catalyst is comprised of the two phases M1 (orthorhombic) Mo7.5V1.5NbTeO29 and M2 (pseudo-hexagonal) Mo4V2Te2O20. Under reaction conditions, the two...
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On the Synergy Effect in MoO3–Fe2(MoO4)3 Catalysts for Methanol Oxidation to Formaldehyde
Methanol oxidation to formaldehyde was studied over a series of Fe–Mo–O catalysts with various Mo/Fe atomic ratio and the end compositions Fe2O3 and MoO3. The activity data show that the specific activity passes ...
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Open AccessPITX2 gain-of-function induced defects in mouse forelimb development
Limb development and patterning originate from a complex interplay between the skeletal elements, tendons, and muscles of the limb. One of the genes involved in patterning of limb muscles is the homeobox trans...
