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Sumoylation of Notch1 represses its target gene expression during cell stress

The Notch signaling pathway is a key regulator of stem cells during development, and its deregulated activity is linked to developmental defects and cancer. Transcriptional activation of Notch target genes req...

Christian J. M. Antila, Vilma Rraklli, Henri A. Blomster… in Cell Death & Differentiation (2018)