16 Result(s)

Article

Differential impact of drugs on the outcome of ETV6-RUNX1 positive childhood B-cell precursor acute lymphoblastic leukaemia: results of the EORTC CLG 58881 and 58951 trials

C Piette, S Suciu, E Clappier, Y Bertrand, S Drunat, S Girard, K Yakouben… in Leukemia (2018)

Article

IKZF1 deletion is an independent prognostic marker in childhood B-cell precursor acute lymphoblastic leukemia, and distinguishes patients benefiting from pulses during maintenance therapy: results of the EORTC Children's Leukemia Group study 58951

The added value of IKZF1 gene deletion (IKZF1^del) as a stratifying criterion in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We performed a comprehensive analysis of the impact of IKZ...

E Clappier, N Grardel, M Bakkus, J Rapion, B De Moerloose, P Kastner, A Caye… in Leukemia (2015)

Article

MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia

The MYB oncogene is a leucine zipper transcription factor essential for normal and malignant hematopoiesis. In T-cell acute lymphoblastic leukemia (T-ALL), elevated MYB levels can arise directly through T-cell re...

E Mets, J Van der Meulen, G Van Peer, M Boice, P Mestdagh, I Van de Walle… in Leukemia (2015)

Article

An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions

Oncogenic subtypes in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) are used for risk stratification. However, a significant number of BCP-ALL patients are still genetically unassigned. Usi...

E Clappier, M-F Auclerc, J Rapion, M Bakkus, A Caye, A Khemiri, C Giroux… in Leukemia (2014)

Article

Flow cytometry and IG/TCR quantitative PCR for minimal residual disease quantitation in acute lymphoblastic leukemia: a French multicenter prospective study on behalf of the FRALLE, EORTC and GRAALL

Minimal residual disease (MRD) quantification is widely used for therapeutic stratification in pediatric acute lymphoblastic leukemia (ALL). A robust, reproducible, sensitivity of at least 0.01% has been achie...

R Garand, K Beldjord, H Cavé, C Fossat, I Arnoux, V Asnafi, Y Bertrand… in Leukemia (2013)

Article

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

Leukemia-initiating/repopulating cells (LICs), also named leukemic stem cells, are responsible for propagating human acute leukemia. Although they have been characterized in various leukemias, their role in T-...

B Gerby, E Clappier, F Armstrong, C Deswarte, J Calvo, S Poglio, J Soulier… in Leukemia (2011)

Article

NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951

Risk-adjusted treatment stratification in T-cell acute lymphoblastic leukemias (T-ALLs) is currently based only on early response to chemotherapy. We investigated the prognostic implication of hyperactivation ...

E Clappier, S Collette, N Grardel, S Girard, L Suarez, G Brunie, S Kaltenbach… in Leukemia (2010)

Article

Wilms tumor 1 (WT1) gene mutations in pediatric T-cell malignancies

A Renneville, S Kaltenbach, E Clappier, S Collette, J-B Micol, B Nelken… in Leukemia (2010)

Article

New insights to the MLL recombinome of acute leukemias

Chromosomal rearrangements of the human MLL gene are associated with high-risk pediatric, adult and therapy-associated acute leukemias. These patients need to be identified, treated appropriately and minimal resi...

C Meyer, E Kowarz, J Hofmann, A Renneville, J Zuna, J Trka, R Ben Abdelali… in Leukemia (2009)

Article

Childhood secondary ALL after ALL treatment

Data on secondary acute lymphoblastic leukaemia (sALL) following ALL treatment are very rare. However, the incidence might be underestimated as sALLs without a significant lineage shift might automatically be ...

J Zuna, H Cavé, C Eckert, T Szczepanski, C Meyer, E Mejstrikova, E Fronkova… in Leukemia (2007)

Article

Clinical, cytogenetic and molecular characteristics of 14 T-ALL patients carrying the TCRβ-HOXA rearrangement: a study of the Groupe Francophone de Cytogénétique Hématologique

Recently, we and others described a new chromosomal rearrangement, that is, inv(7)(p15q34) and t(7;7)(p15;q34) involving the T-cell receptor beta (TCRβ) (7q34) and the HOXA gene locus (7p15) in 5% of T-cell acute...

B Cauwelier, H Cavé, C Gervais, M Lessard, C Barin, C Perot, J Van den Akker… in Leukemia (2007)

Article

HOXA cluster deregulation in T-ALL associated with both a TCRD-HOXA and a CALM-AF10 chromosomal translocation

J Bergeron, E Clappier, B Cauwelier, N Dastugue, C Millien, E Delabesse… in Leukemia (2006)

Article

Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias

Strong expression of at least one of the three D-type cyclins is common in human cancers. While the cyclin D1 and D3 genes (CCND1 and CCND3) are recurrently involved in genomic rearrangements, especially in B-cel...

E Clappier, W Cuccuini, J-M Cayuela, D Vecchione, A Baruchel, H Dombret… in Leukemia (2006)