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136 Result(s)
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Article
Open AccessEfficient and tunable white-light emission of metal–organic frameworks by iridium-complex encapsulation
Metal–organic frameworks (MOFs) are well known for their tunable structure and porosity. Many studies have shown they are promising for various important applications, for which their performance can be furthe...
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Open AccessReal-Time Light Scattering Tracking of Gold Nanoparticles- bioconjugated Respiratory Syncytial Virus Infecting HEp-2 Cells
Real-time tracking of virus invasion is crucial for understanding viral infection mechanism, which, however, needs simple and efficient labeling chemistry with improved signal-to-noise ratio. For that purpose,...
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Open AccessLabel-free detection of kanamycin based on a G-quadruplex DNA aptamer-based fluorescent intercalator displacement assay
This work was the first to report that the kanamycin-binding DNA aptamer (5′-TGG GGG TTG AGG CTA AGC CGA-3′) can form stable parallel G-quadruplex DNA (G4-DNA) structures by themselves and that this phenomenon...
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Open AccessAncient inland human dispersals from Myanmar into interior East Asia since the Late Pleistocene
Given the existence of plenty of river valleys connecting Southeast and East Asia, it is possible that some inland route(s) might have been adopted by the initial settlers to migrate into the interior of East ...
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Open AccessUbiquitin-protein ligase E3C promotes glioma progression by mediating the ubiquitination and degrading of Annexin A7
The ubiquitin-protein ligase E3C (UBE3C) belongs to the E3 ligase enzyme family and implicates in the ubiquitin-proteasome pathway, thus regulates physiological and cancer-related processes. Here, we investiga...
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Open AccessGeneration of inheritable and “transgene clean” targeted genome-modified rice in later generations using the CRISPR/Cas9 system
The CRISPR/Cas9 system is becoming an important genome editing tool for crop breeding. Although it has been demonstrated that target mutations can be transmitted to the next generation, their inheritance patte...
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Open AccessStructural, energetic and dynamic insights into the abnormal xylene separation behavior of hierarchical porous crystal
Separation of highly similar molecules and understanding the underlying mechanism are of paramount theoretical and practical importance, but visualization of the host-guest structure, energy, or dynamism is ve...
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Open AccessA systematic analysis of human lipocalin family and its expression in esophageal carcinoma
The lipocalin proteins (lipocalins) are a large family of small proteins characterized by low sequence similarity and highly conserved crystal structures. Lipocalins have been found to play important roles in ...
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Open AccessLarge-scale genomics unveil polygenic architecture of human cortical surface area
Little is known about how genetic variation contributes to neuroanatomical variability, and whether particular genomic regions comprising genes or evolutionarily conserved elements are enriched for effects tha...
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Article
Open AccessmiRNA-133 augments coelomocyte phagocytosis in bacteria-challenged Apostichopus japonicus via targeting the TLR component of IRAK-1 in vitro and in vivo
In this study, we explored the potential roles of miRNA-133 in regulating TLR pathways in the sea cucumber Apostichopus japonicus. Target screening of RNA-Seq data successfully identified interleukin-1 receptor-a...
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Open AccessAccommodating lithium into 3D current collectors with a submicron skeleton towards long-life lithium metal anodes
Lithium metal is one of the most attractive anode materials for electrochemical energy storage. However, the growth of Li dendrites during electrochemical deposition, which leads to a low Coulombic efficiency ...
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Open AccessDissolution-and-reduction CVD synthesis of few-layer graphene on ultra-thin nickel film lifted off for mode-locking fiber lasers
The in-situ dissolution-and-reduction CVD synthesized few-layer graphene on ultra-thin nickel catalyst film is demonstrated at temperature as low as 550 °C, which can be employed to form transmission-type or refl...
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Open AccessModeling the interplay between the HIF-1 and p53 pathways in hypoxia
Both the hypoxia-inducible factor-1 (HIF-1) and tumor suppressor p53 are involved in the cellular response to hypoxia. How the two transcription factors interact to determine cell fates is less well understood...
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Open AccessInteraction between microRNA expression and classical risk factors in the risk of coronary heart disease
The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesio...
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Open AccessAncient Chinese Formula Qiong-Yu-Gao Protects Against Cisplatin-Induced Nephrotoxicity Without Reducing Anti-tumor Activity
Cisplatin is a highly effective anti-cancer chemotherapeutic agent; however, its clinical use is severely limited by serious side effects, of which nephrotoxicity is the most important. In this study, we inves...
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Article
Open AccessScreening and Molecular Analysis of Single Circulating Tumor Cells Using Micromagnet Array
Immunomagnetic assay has been developed to detect rare circulating tumor cells (CTCs), which shows clinical significance in cancer diagnosis and prognosis. The generation and fine-tuning of the magnetic field ...
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Open AccessHemicelluloses/montmorillonite hybrid films with improved mechanical and barrier properties
A facile and environmentally friendly method was introduced to incorporate montmorillonite (MMT) as an inorganic phase into quaternized hemicelluloses (QH) for forming hemicellulose-based films. Two fillers, p...
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Open AccessTreating Colon Cancer Cells with FK228 Reveals a Link between Histone Lysine Acetylation and Extensive Changes in the Cellular Proteome
The therapeutic value of FK228 as a cancer treatment option is well known and various types of cancer have been shown to respond to this drug. However, the complete mechanism of FK228 and the affect it has on ...
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Open AccessThe Roles of MicroRNA-122 Overexpression in Inhibiting Proliferation and Invasion and Stimulating Apoptosis of Human Cholangiocarcinoma Cells
Our study investigated whether microRNA-122 (miR-122) played important roles in the proliferation, invasion and apoptosis of human cholangiocarcinoma (CC) cells. QBC939 and RBE cells lines were chosen and divi...
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Open AccessTXNIP/TRX/NF-κB and MAPK/NF-κB pathways involved in the cardiotoxicity induced by Venenum Bufonis in rats
Venenum Bufonis (VB) is a widely used traditional medicine with serious cardiotoxic effects. The inflammatory response has been studied to clarify the mechanism of the cardiotoxicity induced by VB for the firs...