16 Result(s)
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Article
Chen-Chang Lee
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Article
Cerebral metabolic changes in neurologically presymptomatic patients undergoing haemodialysis: in vivo proton MR spectroscopic findings
To prospectively investigate and detect early cerebral metabolic changes in patients with end-stage renal disease (ESRD) by using in vivo proton MR spectroscopy (MRS).
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Modeling spatial fracture intensity as a control on flow in fractured rock
Spatial fracture intensity (P 32, fracture area by volume) is an important characteristic of a jointed rock mass. Although it can hardly ever be measured, P 32 can ...
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Open AccessClinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is a common form of focal epilepsy. Serum biomarkers to predict cognitive performance in TLE patients without psychiatric comorbidities and the link with gray matter (GM) atrophy h...
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Diffusion-weighted imaging improves prediction in cognitive outcome and clinical phases in patients with carbon monoxide intoxication
Changes in apparent diffusion coefficient (ADC) values often reflect tissue injury. Use of ADC as a surrogate marker to assess clinical phases has not been systemically applied in patients with carbon monoxide...
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Article
Cancer Patient–Derived Circulating Microparticles Enhance Lung Metastasis in a Rat Model: Dual-Source CT, Cellular, and Molecular Studies
This study aimed to test the hypothesis that lung cancer patient–derived circulating microparticles (LCC-MPs) enhance metastatic lung tumors in a rat model.
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Open AccessGenetic effect of interleukin-1 beta (C-511T) polymorphism on the structural covariance network and white matter integrity in Alzheimer’s disease
Inflammatory processes play a pivotal role in the degenerative process of Alzheimer’s disease. In humans, a biallelic (C/T) polymorphism in the promoter region (position-511) (rs16944) of the interleukin-1 bet...
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Open AccessSevere bilateral ischemic-reperfusion renal injury: hyperacute and acute changes in apparent diffusion coefficient, T1, and T2 map** with immunohistochemical correlations
The aim of this study was to investigate the hyperacute and acute changes in apparent diffusion coefficient (ADC), T1, and T2 map** in rat kidneys after severe bilateral renal ischemic-reperfusion injury (IR...
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Open AccessEffects of Homocysteine on white matter diffusion parameters in Alzheimer’s disease
The clinical features of Alzheimer’s disease (AD) are related to brain network degeneration, and hyperhomocysteinemia is related to greater white matter hyperintensities. We investigated the changes in four di...
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Open AccessCerebral Perfusion Insufficiency and Relationships with Cognitive Deficits in Alzheimer’s Disease: A Multiparametric Neuroimaging Study
Micro- or macro-circulatory insufficiency has a negative impact in patients with Alzheimer’s disease (AD). This study used arterial spin-labeled magnetic resonance imaging (ASL-MRI) and ethylcysteinate dimer s...
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Open AccessAssociations of Bcl-2 rs956572 genotype groups in the structural covariance network in early-stage Alzheimer’s disease
Alzheimer’s disease (AD) is a complex neurodegenerative disease, and genetic differences may mediate neuronal degeneration. In humans, a single-nucleotide polymorphism in the B-cell chronic lymphocytic leukemi...
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Open AccessCatechol-O-Methyltransferase Val158Met Polymorphism on Striatum Structural Covariance Networks in Alzheimer’s Disease
The catechol-O-methyltransferase enzyme metabolizes dopamine in the prefrontal axis, and its genetic polymorphism (rs4680; Val158Met) is a known determinant of dopamine signaling. In this study, we investigate...
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Apparent Diffusion Coefficient is a Useful Biomarker for Monitoring Adipose-Derived Mesenchymal Stem Cell Therapy of Renal Ischemic-Reperfusion Injury
This study aimed to investigate the potential of apparent diffusion coefficient (ADC) for monitoring adipose-derived mesenchymal stem cell (ADMSC) therapy of renal ischemic-reperfusion injury (IRI).
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MAOA-VNTR Genotype Effects on Ventral Striatum-Hippocampus Network in Alzheimer’s Disease: Analysis Using Structural Covariance Network and Correlation with Neurobehavior Performance
Functional polymorphisms in the promoter region of the monoamine oxidase A (MAOA) gene are associated with brain MAOA activity and transcriptional efficiency in patients with Alzheimer’s disease (AD). This study ...
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Open AccessABCA7 polymorphisms correlate with memory impairment and default mode network in patients with APOEε4-associated Alzheimer’s disease
Since both APOE and ABCA7 protein expression may independently reduce neuritic plaque burden and reorganize fibrillar amyloid burden-mediated disruption of functional connectivity in the default mode network, we ...
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Renal Damages in Deoxycorticosterone Acetate–Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-map**
This study aimed to investigate the feasibility of diffusion tensor imaging (DTI) and T2-map** to assess temporal renal damage in deoxycorticosterone acetate–salt (DOCA-salt) hypertensive rats and compare th...
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Open AccessThe use of individual-based FDG-PET volume of interest in predicting conversion from mild cognitive impairment to dementia
Based on a longitudinal cohort design, the aim of this study was to investigate whether individual-based 18F fluorodeoxyglucose positron emission tomography (18F-FDG-PET) regional signals can predict dementia con...
