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    Article

    Intelligent MIMO ORFBLS-Based Setpoint Tracking Control with Its Application to Temperature Control of an Industrial Extrusion Barrel

    This paper presents a novel intelligent control method using an output recurrent fuzzy broad learning system (ORFBLS) for robust setpoint tracking control of nonlinear digital multi-input multi-output (MIMO) t...

    Ali Rospawan, Ching-Chih Tsai, Chi-Chih Hung in International Journal of Fuzzy Systems (2024)

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    Article

    Intelligent Actor-Critic Learning Control for Collison-Free Trajectory Tracking of Mecanum-Wheeled Mobile Robots

    In the paper, an intelligent actor-critic learning control method augmented by a fuzzy broad learning system with output recurrent feedback (abbreviated as ORFBLS) is proposed for obstacle-avoiding trajectory ...

    Ching-Chih Tsai, Hsing-Yi Chen, Chun-Chieh Chan in International Journal of Fuzzy Systems (2024)

  3. Article

    Open Access

    The prognostic value of URR equals that of Kt/V for all-cause mortality in Taiwan after 10-year follow-up

    Kt/V and URR (urea reduction ratio) measurements represent dialysis adequacy. Single-pool Kt/V is theoretically a superior method and is recommended by the Kidney Disease Outcomes Quality Initiative guidelines...

    Yi-Kong Chen, Chih-Sheng Chu, Sheng-Wen Niu, Hugo You-Hsien Lin in Scientific Reports (2023)

  4. Article

    Open Access

    PKD2 founder mutation is the most common mutation of polycystic kidney disease in Taiwan

    Autosomal Dominant polycystic kidney disease (ADPKD) is the most common inherited adult kidney disease. Although ADPKD is primarily caused by PKD1 and PKD2, the identification of several novel causative genes in ...

    Chih-Chuan Yu, An-Fu Lee, Stefen Kohl, Ming-Yen Lin, Siao Muk Cheng in npj Genomic Medicine (2022)

  5. Article

    Open Access

    Low serum iron is associated with anemia in CKD stage 1–4 patients with normal transferrin saturations

    Low transferrin saturation (TSAT), calculated by serum iron divided by total iron-binding capacity (TIBC), indicates iron deficiency. Because malnutrition and inflammation are associated with low TIBC in chron...

    Pei-Hua Yu, Ming-Yen Lin, Yi-Wen Chiu, Jia-Jung Lee, Shang-Jyh Hwang in Scientific Reports (2021)

  6. Article

    Open Access

    Pyuria, urinary tract infection and renal outcome in patients with chronic kidney disease stage 3–5

    Pyuria is common in chronic kidney disease (CKD), which could be due to either urinary tract infection (UTI) or renal parenchymal inflammation. Only little is known regarding the association of pyuria or UTI w...

    I-Ching Kuo, Jia-Jung Lee, Daw-Yang Hwang, Lee-Moay Lim in Scientific Reports (2020)

  7. No Access

    Article

    Renal Damages in Deoxycorticosterone Acetate–Salt Hypertensive Rats: Assessment with Diffusion Tensor Imaging and T2-map**

    This study aimed to investigate the feasibility of diffusion tensor imaging (DTI) and T2-map** to assess temporal renal damage in deoxycorticosterone acetate–salt (DOCA-salt) hypertensive rats and compare th...

    Sheung-Fat Ko, Hon-Kan Yip, Yen-Yi Zhen, Chi-Chih Hung in Molecular Imaging and Biology (2020)

  8. Article

    Open Access

    Diabetic Retinopathy and Clinical Parameters Favoring the Presence of Diabetic Nephropathy could Predict Renal Outcome in Patients with Diabetic Kidney Disease

    Diabetes duration, diabetic retinopathy (DR), and a diagnostic model have been proposed as clinical parameters favoring the presence of diabetic nephropathy (DN) in biopsied patients with diabetic kidney disea...

    Chi-Chih Hung, Hugo You-Hsien Lin, Daw-Yang Hwang, I-Ching Kuo in Scientific Reports (2017)

  9. Article

    Open Access

    Association of Renal Elasticity and Renal Function Progression in Patients with Chronic Kidney Disease Evaluated by Real-Time Ultrasound Elastography

    Glomerulosclerosis and tubulointerstitial fibrosis are associated with lower renal parenchymal elasticity. This study was designed to evaluate the predictive ability of renal elasticity in patients with chroni...

    Hugo You-Hsien Lin, Yu-Li Lee, Kun-Der Lin, Yi-Wen Chiu in Scientific Reports (2017)

  10. Article

    Open Access

    Glycosuria and Renal Outcomes in Patients with Nondiabetic Advanced Chronic Kidney Disease

    Sodium glucose cotransporter 2 inhibitors have shown a potential for renoprotection beyond blood glucose lowering. Glycosuria in nondiabetic patients with chronic kidney disease (CKD) is sometimes noted. Wheth...

    Chi-Chih Hung, Hugo You-Hsien Lin, Jia-Jung Lee, Lee Moay Lim in Scientific Reports (2016)

  11. Article

    Open Access

    Hyponatremia is Associated with Fluid Imbalance and Adverse Renal Outcome in Chronic Kidney Disease Patients Treated with Diuretics

    Chronic kidney disease (CKD) is frequently complicated with hyponatremia, probably because of fluid overload or diuretic usage. Hyponatremia in CKD population is associated with increased mortality, but the ef...

    Lee Moay Lim, Ni-Chin Tsai, Ming-Yen Lin, Daw-Yang Hwang in Scientific Reports (2016)

  12. Article

    Open Access

    Glycated Hemoglobin and Outcomes in Patients with Advanced Diabetic Chronic Kidney Disease

    Diabetes is the major risk factor for end-stage renal disease (ESRD) worldwide. In advanced chronic kidney disease (CKD), less is known about the predictive value of HbA1c. We enrolled 2401 diabetic patients w...

    I-Ching Kuo, Hugo You-Hsien Lin, Sheng-Wen Niu, Daw-Yang Hwang in Scientific Reports (2016)

  13. Article

    Open Access

    Microscopic Haematuria and Clinical Outcomes in Patients With Stage 3–5 Nondiabetic Chronic Kidney Disease

    Microscopic haematuria is proposed as a prognostic factor for renal outcomes in patients with glomerulonephritis. However, the role of haematuria in patients with advanced chronic kidney disease (CKD) or heavy...

    Hugo You-Hsien Lin, Chun-Yu Yen, Lee-Moay Lim, Daw-Yang Hwang in Scientific Reports (2015)

  14. Article

    Open Access

    Low serum calcium is associated with poor renal outcomes in chronic kidney disease stages 3–4 patients

    Mineral disorders are associated with adverse renal outcomes in chronic kidney disease (CKD) patients. Previous studies have associated hypercalcemia and hypocalcemia with mortality; however, the association b...

    Lee-Moay Lim, Hung-Tien Kuo, Mei-Chuan Kuo, Yi-Wen Chiu, Jia-Jung Lee in BMC Nephrology (2014)

  15. Article

    Open Access

    Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines

    Mammalian target of rapamycin (mTOR) inhibitors, such as sirolimus and its derivative, everolimus, are potent immunosuppressive and antiproliferative drugs. Inflammatory diseases are characterized by immunolog...

    Hugo You-Hsien Lin, Kai-Ting Chang, Chi-Chih Hung, Chang-Hung Kuo in BMC Immunology (2014)

  16. No Access

    Article

    A kinetic study of thermal degradations of chitosan/polycaprolactam blends

    We have used FT-IR spectra to explain the effects of hydrogen bonding between chitosan and polycaprolactam (PA6). A dynamic mechanical analysis study suggested that the optimum chitosan and PA6 miscibility und...

    Shen-Kun Liao, Chi-Chih Hung, Ming-Fung Lin in Macromolecular Research (2004)