7 Result(s)
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Article
Charna Dibner
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Article
Open AccessClass 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis
Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain not fully understood. Surprisi...
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Open AccessInfluence of circadian clocks on adaptive immunity and vaccination responses
The adaptive immune response is under circadian control, yet, why adaptive immune reactions continue to exhibit circadian changes over long periods of time is unknown. Using a combination of experimental and m...
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Open AccessCircadian clocks guide dendritic cells into skin lymphatics
Migration of leukocytes from the skin to lymph nodes (LNs) via afferent lymphatic vessels (LVs) is pivotal for adaptive immune responses1,2. Circadian rhythms have emerged as important regulators of leukocyte tra...
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Open AccessMulti-technique comparison of atherogenic and MCD NASH models highlights changes in sphingolipid metabolism
Lipotoxicity is a key player in the pathogenesis of nonalcoholic steatohepatitis (NASH), a progressive subtype of nonalcoholic fatty liver disease (NAFLD). In the present study, we combine histological, transc...
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Cellular circadian period length inversely correlates with HbA1c levels in individuals with type 2 diabetes
The circadian system plays an essential role in regulating the timing of human metabolism. Indeed, circadian misalignment is strongly associated with high rates of metabolic disorders. The properties of the ci...
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MicroRNAs modulate core-clock gene expression in pancreatic islets during early postnatal life in rats
Evidence continues to emerge detailing a fine-tuning of the regulation of metabolic processes and energy homeostasis by cell-autonomous circadian clocks. Pancreatic beta cell functional maturation occurs after...
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Open AccessA software solution for recording circadian oscillator features in time-lapse live cell microscopy
Fluorescent and bioluminescent time-lapse microscopy approaches have been successfully used to investigate molecular mechanisms underlying the mammalian circadian oscillator at the single cell level. However, ...
