-
Article
Open AccessPerturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
Perturbed neuronal migration and circuit development have been implicated in the pathogenesis of neurodevelopmental diseases; however, the direct steps linking these developmental errors to behavior alteration...
-
Protocol
Generation of Human Cell Lines Using Lentiviral-Mediated Genetic Engineering
Even now, most human cell lines used in research are derived from tumor cells. They are still widely used because they grow well in vitro and so far have helped answering several basic biological questions. Ho...
-
Protocol
Lentiviral Vectors
Lentiviral vectors have evolved over the last decade as powerful, reliable, and safe tools for stable gene transfer in a wide variety of mammalian cells. Contrary to other vectors derived from oncoretroviruses...
-
Article
Open AccessA software solution for recording circadian oscillator features in time-lapse live cell microscopy
Fluorescent and bioluminescent time-lapse microscopy approaches have been successfully used to investigate molecular mechanisms underlying the mammalian circadian oscillator at the single cell level. However, ...
-
Article
A role for atm in E-cadherin-mediated contact inhibition in epithelial cells
Ataxia telangiectasia is a hereditary pleiomorphic syndrome caused by loss of Atm, a phosphoprotein involved in multiple signaling pathways. Here, we propose a novel role for atm in cultured epithelial cells, ...
