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Article
Open AccessEnhanced photodynamic destruction of a transplantable fibrosarcoma using photochemical internalisation of gelonin
Photochemical internalisation (PCI) is a technique for releasing biologically active macromolecules from endocytic vesicles by light activation of a photosensitiser localised in the same vesicles of targeted c...
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Article
Open AccessNitrogen-containing bisphosphonates inhibit cell cycle progression in human melanoma cells
Cutaneous melanoma is one of the highly malignant human tumours, due to its tendency to generate early metastases and its resistance to classical chemotherapy. We recently demonstrated that pamidronate, a nitr...
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Article
Open AccessDecreased DNA-PK activity in human cancer cells exhibiting hypersensitivity to low-dose irradiation
Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to i...
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Article
Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancers
The distribution of Gp 170, a multidrug resistance (MDR) associated glycoprotein, also called P-glycoprotein (P-gp), was examined by immunohistochemistry, using C219 and MRK16 monoclonal antibodies. Sixty-five...
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Article
Decreased hepatic function in patients with hepatoma or liver metastasis monitored by a hepatocyte specific galactosylated radioligand
99mTc-galactosylated neoglycoalbumin (99mTc-NGA) is a hepatocyte-specific tracer that, after injection into the blood stream, delivers radioactivity selectively to the liver. This is based upon chemical recogn...
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Article
Decreased production of soluble interleukin 2 receptor by phytohaemagglutinin-stimulated peripheral blood mononuclear cells in patients with breast cancer after adjuvant therapy