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Article
Open AccessNingetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
FMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually associated with poor patient prognosis. With advancements in molecular...
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Article
Open AccessPlasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal pla...
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Article
Open AccessInfluence of Gadoxetate disodium to the hepatic proton density fat fraction quantified with the Dixon sequences in a rabbit model
To study the impact of Gx on quantification of hepatic fat contents under metabolic dysfunction-associated steatotic liver disease (MASLD) imaged on VIBE Dixon in hepatobiliary specific phase.
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Open AccessUnrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia
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Article
Open AccessLetermovir Effectively Prevents Cytomegalovirus Infection in Patients with Aplastic Anemia After Hematopoietic Stem Cell Transplantation: A Real-World Retrospective Cohort Study
In this single-center retrospective cohort study, we investigated the efficacy of letermovir in preventing Cytomegalovirus (CMV) infection in patients with aplastic anemia (AA) who have undergone allogeneic hemat...
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Article
Preparation of Carbon Dots from PET Waste by One-step Hydrothermal Method and its Application in Light Blocking Films and LEDs
An environmentally friendly PET-based Carbon Dots (PET-CDs) with excellent fluorescence properties were prepared with waste PET bottle, pyromellitic acid and ammonia water as raw materials by one-step hydrothe...
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Article
Open AccessA novel retinoic acid drug, EYE-502, inhibits choroidal neovascularization by targeting endothelial cells and pericytes
Choroidal neovascularization (CNV) occurs in neovascular age-related macular degeneration (AMD) and often leads to permanent visual impairment. Intravitreal injection of anti-vascular endothelial growth factor...
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Article
Open AccessIdentification of a novel prognosis-associated ceRNA network in lung adenocarcinoma via bioinformatics analysis
Lung adenocarcinoma (LUAD) is the most common subtype of nonsmall-cell lung cancer (NSCLC) and has a high incidence rate and mortality. The survival of LUAD patients has increased with the development of targe...
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Article
Outcome of allogeneic hematopoietic stem cell transplantation for hypoplastic myelodysplastic syndrome
The prognosis of patients with hypoplastic myelodysplastic syndrome (hMDS) after receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. This study aimed to evaluate the outco...
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Article
Open AccessFBI-1 enhanced the resistance of triple-negative breast cancer cells to chemotherapeutic agents via the miR-30c/PXR axis
The factor that binds to the inducer of short transcripts‐1 (FBI-1) is a transcription suppressor and an important proto‐oncogene that plays multiple roles in carcinogenesis and therapeutic resistance. In the ...
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Article
Inguinal hernia repair by Bianchi incision in boys: a retrospective study
Open inguinal hernia repair by Bianchi incision is a potential alternative technique for the treatment of IH. This study aims to retrospectively analyze boys with IH, who underwent open IH repair by Bianchi in...
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Article
Vascular and perivascular niches, but not the osteoblastic niche, are numerically restored following allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia
Bone marrow (BM) niches, including the osteoblastic, vascular, and perivascular niches, are numerically impaired in patients with aplastic anemia (AA). It remains unclear whether these niches are numerically r...
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Article
Open AccessTemporal variation for fractional heat equations with additive white noise
Let u ( t , ...
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Article
Impairment of hematopoietic stem cell niches in patients with aplastic anemia
Aplastic anemia (AA) is a serious hematological disorder characterized by pancytopenia and defective bone marrow (BM) microenvironment. Previous investigations have demonstrated that there is a defect of angio...
