48 Result(s)
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Open AccessInhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive. Protein kinase C-delta (PKC-δ) plays critical roles in the co...
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Open AccessPOU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells.
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Correction: The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis
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Preface for special issue on nonlinear dynamics modeling and control for brain science and brain-like intelligence
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A computational network dynamical modeling for abnormal oscillation and deep brain stimulation control of obsessive–compulsive disorder
Obsessive–compulsive disorder (OCD) is associated with multi-nodal abnormalities in brain networks, characterized by recurrent intrusive thoughts (obsessions) and repetitive behaviours or mental acts (compulsi...
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N4-acetylcytidine of Nop2 mRNA is required for the transition of morula-to-blastocyst
N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) modification is crucial for mRNA stability and translation efficiency, yet the underlying function in mammalian preimplantation embryos remains unc...
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A biophysical model for dopamine modulating working memory through reward system in obsessive–compulsive disorder
Dopamine modulates working memory in the prefrontal cortex (PFC) and is crucial for obsessive–compulsive disorder (OCD). However, the mechanism is unclear. Here we establish a biophysical model of the effect o...
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CISD2 Promotes Proliferation of Colorectal Cancer Cells by Inhibiting Autophagy in a Wnt/β-Catenin-Signaling-Dependent Pathway
The aim of this study is to investigate the role of CDGSH iron-sulfur domain 2 (CISD2) in colorectal cancer (CRC). The purpose of this study was to investigate the role of CDGSH iron-sulfur domain 2 (CISD2) in...
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Excited-state intermediates in a designer protein encoding a phototrigger caught by an X-ray free-electron laser
One of the primary objectives in chemistry research is to observe atomic motions during reactions in real time. Although X-ray free-electron lasers (XFELs) have facilitated the capture of reaction intermediate...
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Model-based optogenetic stimulation to regulate beta oscillations in Parkinsonian neural networks
Optogenetic stimulation, an effective stimulation technique, is applied to the treatment of Parkinson’s disease (PD) to compete with the current neuromodulation technology that focuses on the electrical stimul...
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Open AccessDeciphering the tRNA-derived small RNAs: origin, development, and future
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development ...
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Discovery of Plasma Membrane-Associated RNAs through APEX-seq
In addition to nucleic acids, a variety of other biomolecules have also been found on the plasma membrane. Although researchers have realized that RNA has the ability to bind to membrane vesicles in vitro, lit...
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Sharp decrease in the Laplacian matrix rank of phase-space graphs: a potential biomarker in epilepsy
In this paper, phase space reconstruction from stereo-electroencephalography data of ten patients with focal epilepsy forms a series of graphs. Those obtained graphs reflect the transition characteristics of ...
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Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas
This study explored the function of microRNAs (miRNAs) in invasive pituitary adenomas (IPA), and developed a microRNA-exosome strategy for the disease treatment. Differentially expressed miRNAs and tumor-assoc...
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Epileptic seizures in a heterogeneous excitatory network with short-term plasticity
Epilepsy involves a diverse group of abnormalities, including molecular and cellular disorders. These abnormalities prove to be associated with the changes in local excitability and synaptic dynamics. Correspo...
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Metal-Organic Frameworks Conjugated Lipase with Enhanced Bio-catalytic Activity and Stability
Covalent immobilization of lipase onto a solid carrier is an effective way to enhance stability. Immobilization inhibits the activity of lipase due to decreased flexibility of enzyme structure via the covalent...
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Open AccessNMMHC IIA triggers neuronal autophagic cell death by promoting F-actin-dependent ATG9A trafficking in cerebral ischemia/reperfusion
Previous findings have shown that non-muscle myosin heavy-chain IIA (NMMHC IIA) is involved in autophagy induction triggered by starvation in D. melanogaster; however, its functional contribution to neuronal auto...
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The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis
Krüppel-like factor 4 (KLF4), a key transcription factor, acts as a multifunctional player involved in the progression of numerous aggressive cancers. The proteasome-dependent pathway is one of the main modali...
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Coupling natural systems with synthetic chemistry for light-driven enzymatic biocatalysis
Visible light-driven redox reactions have been widely adopted for the production of chemicals to combat energy shortage and global warming. Key elements of such a reaction system include a photosensitizer, a c...
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Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia
Ventricular tachycardia (VT) causes sudden cardiac death, however, the majority of risk genes for VT remain unknown. SCN4B encodes a β-subunit, Navβ4, for the voltage-gated cardiac sodium channel complex involved...
