10 Result(s)
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Article
**aqing Chen
Biomedicine
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Article
Open AccessRunx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice
After spinal cord injury, astrocytes undergo a reactive process and form an astroglial scar, which impedes the regeneration of axons. The role of Runx2 in promoting the transformation of astrocytes in the cent...
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Open AccessA novel PDPN antagonist peptide CY12-RP2 inhibits melanoma growth via Wnt/β-catenin and modulates the immune cells
Podoplanin (PDPN) is a highly conserved, mucin-type protein specific to the lymphatic system. Overexpression of PDPN is associated with the progression of various solid tumors, and plays an important roles in ...
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De novo transcriptome sequencing of the northern fowl mite, Ornithonyssus sylviarum, shed light on parasitiform poultry mites evolution and its chemoreceptor repertoires
The northern fowl mite (NFM), Ornithonyssus sylviarum, and the poultry red mite (PRM), Dermanyssus gallinae, are the most serious pests of poultry, both of which have an expanding global prevalence. Research on N...
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Perspectives on Animal Models Utilized for the Research and Development of Regenerative Therapies for Articular Cartilage
Animal models are integral and indispensable for biomedical research and regenerative medicine studies, as these provide invaluable information for systemically evaluating the potential risks and efficacy of n...
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LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mous...
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Distractor removal amplifies spatial frequency-specific crossover of the attentional bias: a psychophysical and Monte Carlo simulation study
Rarely noticed in daily life, attention may prefer the left side of space. Such attentional biases offer key insights into functions of spatial attention and visual awareness because they complement pathologic...
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A new Model Consists of Intravesical Prostatic Protrusion, Prostate Volume and Serum Prostatic-Specific Antigen in the Evaluation of Prostate Cancer
The Prostate-specific antigen (PSA) level is largely used to diagnose prostate cancer (PCa) in last decades. However, its specificity is low in patients with a PSA level ranging from 4.0 to 10.0 ng/ml. This st...
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Do head-on-trunk signals modulate disengagement of spatial attention?
Body schema is indispensable for sensorimotor control and learning, but whether it is associated with cognitive functions, such as allocation of spatial attention, remains unclear. Observations in patients wi...
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Potentiation of the Immune System by Schiff Base-Forming Drugs
CD4+ T lymphocytes, which orchestrate immune responses, receive a cognitive signal when clonally distributed receptors are occupied by peptides bound to major histocompatibility complex (MHC) class II molecule...
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Bridging Schwann cell transplants promote axonal regeneration from both the rostral and caudal stumps of transected adult rat spinal cord
Transplantation of cellular components of the permissive peripheral nerve environment in some types of spinal cord injury holds great promise to support regrowth of axons through the site of injury. In the pre...
