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Article
Social Media and Adolescent Mental Health
This review delves into the intricate relationship between social media and adolescent mental health, scrutinizing underlying psychological mechanisms and proposing directions for future inquiry and interventi...
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Article
Status and influential factors of spiritual well-being in cancer patients with drug clinical trials: a cross-sectional study
The purpose of this study was to investigate the spiritual well-being status of cancer patients in drug clinical trials and its influencing factors, and to provide theoretical support for the spiritual health ...
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Article
Assessing the thrombosis risk of peripherally inserted central catheters in cancer patients using Caprini risk assessment model: a prospective cohort study
There was no optimal risk assessment tool to stratify the risk of peripherally inserted central catheter-related venous thromboembolism (PICC-RVT) in cancer patients. We currently use the Caprini risk assessme...
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Article
Open AccessSUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis
Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and proliferative activities in cancer cells. The binding of hexokinase 2 to the outer membrane of mitochondria is critical for...
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Article
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption
LGR4 has been identified as a new receptor for RANKL in bone cells where it opposes RANK signaling to inhibit osteoclasts differentiation, and its therapeutic targeting promotes reduced bone loss in three mous...
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Article
Open AccessInhibition of Osteoclastogenesis and Bone Resorption in vitro and in vivo by a prenylflavonoid xanthohumol from hops
Excessive RANKL signaling leads to superfluous osteoclast formation and bone resorption, is widespread in the pathologic bone loss and destruction. Therefore, targeting RANKL or its signaling pathway has been ...