-
Article
Mechanism of Antidepressant Action of (2R,6R)-6-Hydroxynorketamine (HNK) and Its Compounds: Insights from Proteomic Analysis
The effects of HNK, I5, and I6 on the expression of protein in hippocampus of depressed mice were studied by isobaric tags for relative and absolute quantitation (iTRAQ) to explore the mechanism of their antid...
-
Article
The Roles of Autophagy in the Genesis and Development of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a common and frequent disease and always leads endocrine and metabolic disorder among women in reproductive age. Ovary is the main organ involved in polycystic ovary syndrom...
-
Article
REGγ controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells
Interleukin-17A (IL-17A)-producing helper T (Th17) cells are a subset of CD4+ T cells that play important pathological roles in autoimmune diseases. Although the intrinsic pathways of Th17 cell differentiation ha...
-
Article
Open AccessInhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer–stromal interaction and metastasis
Extracellular signal-regulated kinases (ERKs) have been related to multiple cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer. ERK1/2 inhibitor can suppress growth of KRAS
-
Article
CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis
This study aimed at investigating the function and significance of CD110 expression in pancreatic cancer.
-
Article
GPR54 deficiency reduces the Treg population and aggravates experimental autoimmune encephalomyelitis in mice
GPR54 is highly expressed in the central nervous system and plays a crucial role in pubertal development. However, GRP54 is also expressed in the immune system, implying possible immunoregulatory functions. He...
-
Article
Primary Recurrence in the Lung is Related to Favorable Prognosis in Patients with Pancreatic Cancer and Postoperative Recurrence
The pattern of recurrence affects the clinical outcome in tumor patients. However, the clinical significance of lung metastasis as the primary recurrence site after resection in patients with pancreatic cancer...
-
Article
Open AccessThe REGγ-proteasome forms a regulatory circuit with IκBɛ and NFκB in experimental colitis
Increasing incidence of inflammatory bowel disorders demands a better understanding of the molecular mechanisms underlying its multifactorial aetiology. Here we demonstrate that mice deficient for REGγ, a prot...
-
Article
Aurora Kinase A Regulates M1 Macrophage Polarization and Plays a Role in Experimental Autoimmune Encephalomyelitis
Macrophage polarization is a dynamic and integral process of tissue inflammation and remodeling. Here we demonstrate an important role of Aurora kinase A in the regulation of inflammatory M1 macrophage polariz...
-
Article
Potentiation of the Immune System by Schiff Base-Forming Drugs
CD4+ T lymphocytes, which orchestrate immune responses, receive a cognitive signal when clonally distributed receptors are occupied by peptides bound to major histocompatibility complex (MHC) class II molecule...
-
Article
Alternative pathways for the selection of antigen-specific peripheral T cells
IN the thymus, maturing lymphocytes receive activation signals mediated by the T-cell antigen receptor (TCR) that either promote clonal survival (positive selection) or induce apoptosis (negative selection). T...
-
Article
Somatic diversification of antibody responses
During the last decade, a substantial body of knowledge has been obtained on the generation of somatic diversification of the B cell repertoire, especially with regard to differentiation and selection of B cel...
-
Article
Hypermutation in T cells questioned
-
Article
Locus-specific somatic hypermutation in germinal centre T cells
SOMATIC hypermutation and affinity-driven selection of active immunoglobulin genes occur in germinal centres (GCs), resulting in the generation of high-affinity memory B cells1–3. In contrast, T lymphocytes do no...
