149 Result(s)
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English
Biomedicine
Animal Genetics and Genomics
Cancer Research
**an Qi
Article
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Open AccessInseparable RNA binding and chromatin modification activities of a nucleosome-interacting surface in EZH2
Polycomb repressive complex 2 (PRC2) interacts with RNA in cells, but there is no consensus on how RNA regulates PRC2 canonical functions, including chromatin modification and the maintenance of transcription ...
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Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits
Methylation quantitative trait loci (mQTLs) are essential for understanding the role of DNA methylation changes in genetic predisposition, yet they have not been fully characterized in East Asians (EAs). Here ...
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Open AccessLarge-scale gene expression alterations introduced by structural variation drive morphotype diversification in Brassica oleracea
Brassica oleracea, globally cultivated for its vegetable crops, consists of very diverse morphotypes, characterized by specialized enlarged organs as harvested products. This makes B. oleracea an ideal model for ...
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Author Correction: Chromosome-level genomes of three key Allium crops and their trait evolution
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Open AccessPangenome analysis reveals genomic variations associated with domestication traits in broomcorn millet
Broomcorn millet (Panicum miliaceum L.) is an orphan crop with the potential to improve cereal production and quality, and ensure food security. Here we present the genetic variations, population structure and di...
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Open AccessRegulatory controls of duplicated gene expression during fiber development in allotetraploid cotton
Polyploidy complicates transcriptional regulation and increases phenotypic diversity in organisms. The dynamics of genetic regulation of gene expression between coresident subgenomes in polyploids remains to b...
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Chromosome-level genomes of three key Allium crops and their trait evolution
Allium crop breeding remains severely hindered due to the lack of high-quality reference genomes. Here we report high-quality chromosome-level genome assemblies for three key Allium crops (Welsh onion, garlic and...
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Open AccessStructure and function of rice hybrid genomes reveal genetic basis and optimal performance of heterosis
Exploitation of crop heterosis is crucial for increasing global agriculture production. However, the quantitative genomic analysis of heterosis was lacking, and there is currently no effective prediction tool ...
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Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma
Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive and HPV-negative oropharyngeal tumo...
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Open AccessPharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection
Identification of host determinants of coronavirus infection informs mechanisms of viral pathogenesis and can provide new drug targets. Here we demonstrate that mammalian SWItch/Sucrose Non-Fermentable (mSWI/S...
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Author Correction: De novo genome assembly and analyses of 12 founder inbred lines provide insights into maize heterosis
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De novo genome assembly and analyses of 12 founder inbred lines provide insights into maize heterosis
Hybrid maize displays superior heterosis and contributes over 30% of total worldwide cereal production. However, the molecular mechanisms of heterosis remain obscure. Here we show that structural variants (SVs...
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Genomic innovation and regulatory rewiring during evolution of the cotton genus Gossypium
Phenotypic diversity and evolutionary innovation ultimately trace to variation in genomic sequence and rewiring of regulatory networks. Here, we constructed a pan-genome of the Gossypium genus using ten represent...
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Histone H3 proline 16 hydroxylation regulates mammalian gene expression
Histone post-translational modifications (PTMs) are important for regulating various DNA-templated processes. Here, we report the existence of a histone PTM in mammalian cells, namely histone H3 with hydroxyla...
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Open AccessGenetic control of RNA splicing and its distinct role in complex trait variation
Most genetic variants identified from genome-wide association studies (GWAS) in humans are noncoding, indicating their role in gene regulation. Previous studies have shown considerable links of GWAS signals to...
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Genomic insights into the recent chromosome reduction of autopolyploid sugarcane Saccharum spontaneum
Saccharum spontaneum is a founding Saccharum species and exhibits wide variation in ploidy levels. We have assembled a high-quality autopolyploid genome of S. spontaneum Np-X (2n = 4x = 40) into 40 pseudochromoso...
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SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma
Mammalian SWI/SNF (mSWI/SNF) ATP-dependent chromatin remodeling complexes establish and maintain chromatin accessibility and gene expression, and are frequently perturbed in cancer. Clear cell meningioma (CCM)...
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BRD2 compartmentalizes the accessible genome
Mammalian chromosomes are organized into megabase-sized compartments that are further subdivided into topologically associating domains (TADs). While the formation of TADs is dependent on cohesin, the mechanis...
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Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice
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Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome
The gut microbiome has been implicated in a variety of physiological states, but controversy over causality remains unresolved. Here, we performed bidirectional Mendelian randomization analyses on 3,432 Chines...
