63 Result(s)

Article

Correction: A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Antitumor activity of Z15-0-2, a bispecific nanobody targeting PD-1 and CTLA-4

The combination of programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA-4) antibodies has potential for enhancing clinical efficacy. We described the development and antitumor acti...

Jianyao Zeng, Yuan Fang, Zixuan Zhang, Zhenzhen Lv, **aodie Wang, Qian Huang… in Oncogene (2024)

Article

A novel survival nomogram for stage I-III acral lentiginous melanoma patients, based on the SEER database and a multi-center external validation cohort

To construct an effective prognostic nomogram for patients with clinically localized Acral lentiginous melanoma (ALM).

Tong Li, Wei Sun, YanWen Luo, Yu Xu, ChunMeng Wang… in Holistic Integrative Oncology (2024)

Article

DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure

DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understo...

Ming**g Yan, Junpeng Gao, Ming Lan, Que Wang… in Signal Transduction and Targeted Therapy (2024)

Article

Tumor biomarkers for diagnosis, prognosis and targeted therapy

Tumor biomarkers, the substances which are produced by tumors or the body’s responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screeni...

Yue Zhou, Lei Tao, Jiahao Qiu, **g Xu… in Signal Transduction and Targeted Therapy (2024)

Article

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease (AD); however, the fundamental mechanism is unknown. In this study, we found a substantial decline in isocitrate dehydrogenase 3β ...

**n Wang, Qian Liu, Hai-tao Yu, Jia-zhao **e… in Signal Transduction and Targeted Therapy (2024)

Article

Phase II study of novel orally PI3Kα/δ inhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

This registration study assessed clinical outcomes of TQ-B3525, the dual phosphatidylinositol-3-kinase (PI3K) α/δ inhibitor, in relapsed and/or refractory follicular lymphoma (R/R FL). This phase II study (Cli...

Huaqing Wang, Jifeng Feng, Yanyan Liu… in Signal Transduction and Targeted Therapy (2024)

Article

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in col...

Ri-**n Chen, Shui-Dan Xu, Min-Hua Deng… in Signal Transduction and Targeted Therapy (2024)

Article

Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment

Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine that can bind to several receptors and mediate distinct molecular pathways in various cell settings. Changing levels of LECT2 have been...

Chin-Jui Wu, Ke-Fan Pan, Ji-Qing Chen, Yu -Chen Tao, Yu-Cheng Liu, Bo-Rong Chen… in Oncogene (2024)

Article

Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape

Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in ...

You Zhai, Yicong Du, Guanzhang Li, Mingchen Yu… in Signal Transduction and Targeted Therapy (2023)

Article

Icariin improves cardiac function and remodeling via the TGF-β1/Smad signaling pathway in rats following myocardial infarction

Postinfarction cardiac remodeling presents a compensatory mechanism aimed at mitigating congestive heart failure. It is distinguished by progressive dilatation and hypertrophy of the ventricular chambers, fibr...

Ji Jia, **ng-an Zhao, Si-ming Tao, Jun-wen Wang… in European Journal of Medical Research (2023)

Article

SNAP25 is a potential target for early stage Alzheimer’s disease and Parkinson’s disease

Alzheimer’s disease (AD) and Parkinson’s disease (PD), two common irreversible neurodegenerative diseases, share similar early stage syndromes, such as olfaction dysfunction. Yet, the potential comorbidity mec...

Qian Wang, Sijue Tao, Lei **ng, Jiuyu Liu… in European Journal of Medical Research (2023)

Article

S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway

Cell senescence deters the activation of various oncogenes. Induction of senescence is, therefore, a potentially effective strategy to interfere with vital processes in tumor cells. Sphingosine-1-phosphate rec...

Yi-** Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-**a Wang, Yu-**n Hua, Han-Yin Hu… in Oncogene (2023)

Article

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement...

**a Xu, Tao Yu, Lingling Dong, Rainer Glauben… in Signal Transduction and Targeted Therapy (2023)

Article

CXXC finger protein 1 (CFP1) bridges the resha** of genomic H3K4me3 signature to the advancement of lung adenocarcinoma

Histone H3 lysine 4 trimethylation (H3K4me3) is a canonical chromatin modification associated with active gene transcription, playing a pivotal role in regulating various cellular functions. Components of the ...

Tao Fan, Chu **ao, Hengchang Liu, Yu Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial

This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in ...

Shun Lu, Hongming Pan, Lin Wu, Yu Yao… in Signal Transduction and Targeted Therapy (2023)

Article

Epigenomic map** identifies an enhancer repertoire that regulates cell identity in bladder cancer through distinct transcription factor networks

Muscle-invasive bladder cancer (BLCA) is an aggressive disease. Consensus BLCA transcriptomic subtypes have been proposed, with two major Luminal and Basal subgroups, presenting distinct molecular and clinical...

Hélène Neyret-Kahn, Jacqueline Fontugne, **ang Yu Meng, Clarice S. Groeneveld… in Oncogene (2023)