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Article
Open AccessNeurofibromin 1 controls metabolic balance and Notch-dependent quiescence of murine juvenile myogenic progenitors
Patients affected by neurofibromatosis type 1 (NF1) frequently show muscle weakness with unknown etiology. Here we show that, in mice, Neurofibromin 1 (Nf1) is not required in muscle fibers, but specifically in e...
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Article
Open AccessCorrection: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
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Article
Open AccessEosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement...
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Article
Open AccessEffects of caloric restriction on the gut microbiome are linked with immune senescence
Caloric restriction can delay the development of metabolic diseases ranging from insulin resistance to type 2 diabetes and is linked to both changes in the composition and metabolic function of the gut microbi...
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Protocol
Fatty Acid–Driven Polarization of Suppressive Bone Marrow–Derived Macrophages Including Metabolic and Functional Analysis
Macrophages represent not only the first line of defense against pathogens and are the main drivers of inflammation but are also involved in the initiation, immune evasion as well as metastasis of tumors. Ther...
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Article
Open AccessLeptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease
Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn’s disease remains sparse. We here describe a patient with...
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Article
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry
Microglia, the specialized innate immune cells of the CNS, play crucial roles in neural development and function. Different phenotypes and functions have been ascribed to rodent microglia, but little is known ...
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Article
Open AccessSoluble mucus component CLCA1 modulates expression of leukotactic cytokines and BPIFA1 in murine alveolar macrophages but not in bone marrow-derived macrophages
The secreted airway mucus cell protein chloride channel regulator, calcium-activated 1, CLCA1, plays a role in inflammatory respiratory diseases via as yet unidentified pathways. For example, deficiency of CLC...
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Article
Open AccessOleate but not stearate induces the regulatory phenotype of myeloid suppressor cells
Tumor infiltrating myeloid cells play contradictory roles in the tumor development. Dendritic cells and classical activated macrophages support anti-tumor immune activity via antigen presentation and induction...
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Article
Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner
Myeloid-derived suppressor cells (MDSCs) are well known for their capacity to suppress antitumor T-cell responses, but their effects on B-cell function and antibody production remain unclear. Here, we found th...
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Article
Open AccessRole of goblet cell protein CLCA1 in murine DSS colitis
The secreted goblet cell protein CLCA1 (chloride channel regulator, calcium-activated-1) is, in addition to its established role in epithelial chloride conductance regulation, thought to act as a multifunction...
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Article
Open AccessInhibition of Histone Deacetylases in Inflammatory Bowel Diseases
This review, comprised of our own data and that of others, provides a summary overview of histone deacetylase (HDAC) inhibition on intestinal inflammation as well as inflammation-mediated carcinogenesis. Exper...
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Protocol
Molecular Basis of Histone Deacetylase Inhibitors as New Drugs for the Treatment of Inflammatory Diseases and Cancer
Histone deacetylase inhibitors are potent inducers of growth arrest and apoptotic cell death and are currently in clinical studies for solid tumors. In addition, recent studies from our own group provide evide...
