279 Result(s)
within
Yu-** Hung
Biomedicine
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Article
Open AccessCHK2 activation contributes to the development of oxaliplatin resistance in colorectal cancer
Colorectal cancer (CRC), the most common cancer type, causes high morbidity and mortality. Patients who develop drug resistance to oxaliplatin-based regimens have short overall survival. Thus, identifying mole...
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Open AccessBiomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) exploit the concept of synthetic lethality and offer great promise in the treatment of tumors with deficiencies in homologous recombination (HR) repair. P...
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Collagen-binding peptides for the enhanced imaging, lubrication and regeneration of osteoarthritic articular cartilage
Treatments for osteoarthritis would benefit from the enhanced visualization of injured articular cartilage and from the targeted delivery of disease-modifying drugs to it. Here, by using ex vivo human osteoart...
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Open AccessThe novel role of ER protein TXNDC5 in the pathogenesis of organ fibrosis: mechanistic insights and therapeutic implications
Fibrosis-related disorders account for an enormous burden of disease-associated morbidity and mortality worldwide. Fibrosis is defined by excessive extracellular matrix deposition at fibrotic foci in the organ...
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Real-World Effects of Biologics on Renal Function in Psoriatic Patients: A Retrospective Study
Patients with severe psoriasis are prone to deterioration of renal function. Whether biologics with potent anti-inflammatory action can prevent deterioration of renal function in psoriatic patients was unclear.
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Open AccessDown-regulated miR-146a expression with increased neutrophil extracellular traps and apoptosis formation in autoimmune-mediated diffuse alveolar hemorrhage
Increasing evidences have suggested an important role of microRNAs (miRNAs) in regulating cell death processes including NETosis and apoptosis. Dysregulated expression of miRNAs and increased formation of neut...
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Open AccessLocalization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity
For centuries, microbial-based agents have been investigated as a therapeutic modality for the treatment of cancer. In theory, these methods would be cheap to produce, broadly applicable in a wide array of can...
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Open AccessFemale breast cancer incidence predisposing risk factors identification using nationwide big data: a matched nested case-control study in Taiwan
Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically...
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Open AccessTrochanteric Nails for the Reduction of Intertrochanteric Fractures: A Biomechanical Analysis Based on Finite Element Analysis and DIC System
Intertrochanteric fractures are common among femoral fractures in the elderly population. The trochanteric nail is a standard internal fixator used in treating femoral intertrochanteric fractures. The techniqu...
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Open AccessEV-miRome-wide profiling uncovers miR-320c for detecting metastatic colorectal cancer and monitoring the therapeutic response
Molecular composition of circulating small extracellular vesicles (EVs) does not merely reflect the cells of origin, but also is enriched in specific biomolecules directly associated with the cellular transfor...
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Open AccessActivation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol
No reports exist as to neuroprotective effects associated with topical activation of transient receptor potential melastatin 8 (TRPM8), a noted cold receptor. In the present study, we identified whether activa...
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Open AccessA dorsal CA2 to ventral CA1 circuit contributes to oxytocinergic modulation of long-term social recognition memory
Social recognition memory (SRM) is the ability to distinguish familiar from novel conspecifics and is crucial for survival and reproductive success across social species. We previously reported that oxytocin (...
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Correction to: Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction
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Open AccessCobalt protoporphyrin promotes human keratinocyte migration under hyperglycemic conditions
Complete healing of diabetic wounds continues to be a clinically unmet need. Although robust therapies such as stem cell therapy and growth factor treatment are clinically applied, these treatments are costly ...
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Open AccessHuman rs75776403 polymorphism links differential phenotypic and clinical outcomes to a CLEC18A p.T151M-driven multiomics
Human traits, diseases susceptibility, and clinical outcomes vary hugely among individuals. Despite a fundamental understanding of genetic (or environmental) contributions, the detailed mechanisms of how genet...
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Article
Open AccessThe power of heteronemin in cancers
Heteronemin (Haimian **g) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticancer properties. It inhibits cancer cell proliferation via different mechanisms, such as ...
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Open AccessInduction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategy
Calls for the coronavirus to be treated as an endemic illness, such as the flu, are increasing. After achieving high coverage of COVID-19 vaccination, therapeutic drugs have become important for future SARS-Co...
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Open AccessCandidate master microRNA regulator of arsenic-induced pancreatic beta cell impairment revealed by multi-omics analysis
Arsenic is a pervasive environmental toxin that is listed as the top priority for investigation by the Agency for Toxic Substance and Disease Registry. While chronic exposure to arsenic is associated with type...
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Article
Exercise Rehabilitation and/or Astragaloside Attenuate Amyloid-beta Pathology by Reversing BDNF/TrkB Signaling Deficits and Mitochondrial Dysfunction
We aim to investigate the mechanisms underlying the beneficial effects of exercise rehabilitation (ER) and/or astragaloside (AST) in counteracting amyloid-beta (Aβ) pathology. Aβ oligomers were microinjected i...
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Open AccessBuilding a model for predicting metabolic syndrome using artificial intelligence based on an investigation of whole-genome sequencing
The circadian system is responsible for regulating various physiological activities and behaviors and has been gaining recognition. The circadian rhythm is adjusted in a 24-h cycle and has transcriptional–tran...
