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Article
Open AccessIntranasal administration of Lactobacillus johnsonii attenuates hyperoxia-induced lung injury by modulating gut microbiota in neonatal mice
Supplemental oxygen impairs lung development in newborn infants with respiratory distress. Lactobacillus johnsonii supplementation attenuates respiratory viral infection in mice and exhibits anti-inflammatory eff...
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Article
Open AccessThe power of heteronemin in cancers
Heteronemin (Haimian **g) is a sesterterpenoid-type natural marine product that is isolated from sponges and has anticancer properties. It inhibits cancer cell proliferation via different mechanisms, such as ...
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Article
Open AccessEndurance exercise ameliorates Western diet–induced atherosclerosis through modulation of microbiota and its metabolites
The World Health Organization determined cardiovascular disease to be the leading cause of death globally; atherosclerosis is the primary cause of the high morbidity and mortality rates. Regular physical activ...
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Article
Maternal antibiotic exposure disrupts microbiota and exacerbates hyperoxia-induced lung injury in neonatal mice
Perinatal antibiotic treatment alters intestinal microbiota and augments hyperoxia-induced lung injury in mice offspring. The effect of maternal antibiotic treatment (MAT) during pregnancy on the lung microbio...
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Article
Open AccessRole of thyroid hormone-integrin αvβ3-signal and therapeutic strategies in colorectal cancers
Thyroid hormone analogues—particularly, l-thyroxine (T4) has been shown to be relevant to the functions of a variety of cancers. Integrin αvβ3 is a plasma membrane structural protein linked to signal transduction...
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Article
Open AccessLong-term Proton Pump Inhibitor Administration Caused Physiological and Microbiota Changes in Rats
Proton pump inhibitors (PPIs) are used for the long-term treatment of gastroesophageal disorders and the non-prescription medicines for acid reflux. However, there is growing concerns about PPI misuse, overuse...
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Article
Thyroid Hormone Promotes β-Catenin Activation and Cell Proliferation in Colorectal Cancer
Thyroid hormone status has long been implicated in cancer development. Here we investigated the role of thyroxine (T4) in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant), as well as th...
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Article
Open AccessLeptin OB3 peptide suppresses leptin-induced signaling and progression in ovarian cancer cells
Obesity and its comorbidities constitute a serious health burden worldwide. Leptin plays an important role in diet control; however, it has a stimulatory potential on cancer cell proliferation. The OB3 peptide...
