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Open AccessLongitudinal fragility phenoty** contributes to the prediction of lifespan and age-associated morbidity in C57BL/6 and Diversity Outbred mice
Aging studies in mammalian models often depend on natural lifespan data as a primary outcome. Tools for lifespan prediction could accelerate these studies and reduce the need for veterinary intervention. Here,...
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Open AccessSEESAW: detecting isoform-level allelic imbalance accounting for inferential uncertainty
Detecting allelic imbalance at the isoform level requires accounting for inferential uncertainty, caused by multi-map** of RNA-seq reads. Our proposed method, SEESAW, uses Salmon and Swish to offer analysis ...
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Open AccessAuthor Correction: Genetic map** of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
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Open AccessMulti-omics analysis identifies drivers of protein phosphorylation
Phosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling cascades. The abundance of a phosphorylated peptide (phosphopeptide) is dete...
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Open AccessGenetic map** of microbial and host traits reveals production of immunomodulatory lipids by Akkermansia muciniphila in the murine gut
The molecular bases of how host genetic variation impacts the gut microbiome remain largely unknown. Here we used a genetically diverse mouse population and applied systems genetics strategies to identify inte...
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Open AccessSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric appr...
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A microbiome-dependent gut–brain pathway regulates motivation for exercise
Exercise exerts a wide range of beneficial effects for healthy physiology1. However, the mechanisms regulating an individual’s motivation to engage in physical activity remain incompletely understood. An importan...
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A machine-vision-based frailty index for mice
Heterogeneity in biological aging manifests itself in health status and mortality. Frailty indices (FIs) capture health status in humans and model organisms. To accelerate our understanding of biological aging...
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Author Correction: Defining the consequences of genetic variation on a proteome-wide scale
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The Jackson Laboratory Nathan Shock Center: impact of genetic diversity on aging
Healthspan is a complex trait, influenced by many genes and environmental factors that accelerate or delay aging, reduce or increase disease risk, and extend or reduce lifespan. Thus, assessing the role of gen...
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Open AccessINFIMA leverages multi-omics model organism data to identify effector genes of human GWAS variants
Genome-wide association studies reveal many non-coding variants associated with complex traits. However, model organism studies largely remain as an untapped resource for unveiling the effector genes of non-co...
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Open AccessPublisher Correction: Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics
An amendment to this paper has been published and can be accessed via the original article.
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A large-scale genome–lipid association map guides lipid identification
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively annotating lipid species and their genetic basis. Mass spectrometry–based discovery lipidomics offers the ...
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Open AccessBayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics
Single-cell RNA sequencing is a powerful tool for characterizing cellular heterogeneity in gene expression. However, high variability and a large number of zero counts present challenges for analysis and inter...
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Open AccessA Bayesian mixture model for the analysis of allelic expression in single cells
Allele-specific expression (ASE) at single-cell resolution is a critical tool for understanding the stochastic and dynamic features of gene expression. However, low read coverage and high biological variabilit...
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Correction: Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Nat. Med. 22, 771–779 (2016); published online 6 June 2016; corrected after print 7 March 2018 In the version of this article initially published, the colors of the lines were switched in the graph that shows ...
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Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Genetic analysis in mice selected for leanness has identified thiosulfate sulfurtransferase as a target for the treatment of diabetes.
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Article
Defining the consequences of genetic variation on a proteome-wide scale
Genetic variation modulates protein expression through both transcriptional and post-transcriptional mechanisms. To characterize the consequences of natural genetic diversity on the proteome, here we combine a...
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Article
Open AccessCollaborative Cross and Diversity Outbred data resources in the Mouse Phenome Database
The Mouse Phenome Database was originally conceived as a platform for the integration of phenotype data collected on a defined collection of 40 inbred mouse strains—the “phenome panel.” This model provided an ...
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Open AccessGenetic properties of the MAGIC maize population: a new platform for high definition QTL map** in Zea mays
Maize (Zea mays) is a globally produced crop with broad genetic and phenotypic variation. New tools that improve our understanding of the genetic basis of quantitative traits are needed to guide predictive crop b...
