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  1. Article

    Open Access

    Forecast of a future leveling of the incidence trends of female breast cancer in Taiwan: an age-period-cohort analysis

    Breast cancer is the most common cancer among women in Taiwan. The age-standardized incidence rate has doubled in just 20 years, causing considerable concern to health professionals and the general public. Thi...

    Yi-Chu Chen, Shih-Yung Su, **g-Rong Jhuang, Chun-Ju Chiang in Scientific Reports (2022)

  2. Article

    Open Access

    Chiral self-sorting and guest recognition of porous aromatic cages

    The synthesis of ultra-stable chiral porous organic cages (POCs) and their controllable chiral self-sorting at the molecular and supramolecular level remains challening. Herein, we report the design and synthe...

    Dong-Xu Cui, Yun Geng, Jun-Ning Kou, Guo-Gang Shan, Chun-Yi Sun in Nature Communications (2022)

  3. Article

    Open Access

    Surgical resection could provide better outcomes for patients with hepatocellular carcinoma and tumor rupture

    We investigated the outcomes of patients with ruptured hepatocellular carcinoma (HCC) and identified the optimal treatment modality for such patients. We retrospectively enrolled 91 patients with treatment-nai...

    Chun-Yang Lee, Gar-Yang Chau, Cheng-Yi Wei, Yee Chao, Yi-Hsiang Huang in Scientific Reports (2022)

  4. Article

    Open Access

    Forecast of peak attainment and imminent decline after 2017 of oral cancer incidence in men in Taiwan

    Oral cancer is the fourth most common cancer among men in Taiwan. The age-standardized incidence rate of oral cancer among men in Taiwan has increased since 1980 and became six times greater in 2014. To enable...

    **g-Rong Jhuang, Shih-Yung Su, Chun-Ju Chiang, Ya-Wen Yang in Scientific Reports (2022)

  5. Article

    Open Access

    Control of crystallization and magnetic properties of CoFeB by boron concentration

    Controlling the crystallinity of CoFeB is the most essential issue for designing various spintronics devices. Here we show the microstructure and magnetic properties of MgO/CoFeB/MgO structures for various bor...

    Jun-Su Kim, Gukcheon Kim, **won Jung, Kuyoul Jung, Jaehun Cho in Scientific Reports (2022)

  6. Article

    Open Access

    Rhythm control without catheter ablation may have benefits beyond stroke prevention in rivaroxaban-treated non-permanent atrial fibrillation

    The current treatment paradigm for atrial fibrillation (AF) prioritizes rate control over rhythm control; however, rhythm control has shown benefits over other AF strategies. This study compares the outcomes o...

    Wei-Ru Chiou, Po-Lin Lin, Chun-Che Huang, Jen-Yu Chuang in Scientific Reports (2022)

  7. No Access

    Article

    Evidence for the association of triatomic molecules in ultracold 23Na40K + 40K mixtures

    Ultracold assembly of diatomic molecules has enabled great advances in controlled chemistry, ultracold chemical physics and quantum simulation with molecules13. Extending the ultracold association to triatomic m...

    Huan Yang, **n-Yao Wang, Zhen Su, ** Cao, De-Chao Zhang, Jun Rui, Bo Zhao in Nature (2022)

  8. Article

    Open Access

    Structure of Vibrio collagenase VhaC provides insight into the mechanism of bacterial collagenolysis

    The collagenases of Vibrio species, many of which are pathogens, have been regarded as an important virulence factor. However, there is little information on the structure and collagenolytic mechanism of Vibrio c...

    Yan Wang, Peng Wang, Hai-Yan Cao, Hai-Tao Ding, Hai-Nan Su in Nature Communications (2022)

  9. Article

    Open Access

    The impact of antimicrobial stewardship program designed to shorten antibiotics use on the incidence of resistant bacterial infections and mortality

    Reassessing the continuing need for and choice of antibiotics by using an antibiotic “time out’’ program may reduce unnecessary treatment. This study aimed to explore the effect of an antibiotic stewardship pr...

    Ling-Ju Huang, Su-Jung Chen, Yu-Wen Hu, Chun-Yu Liu, **-Feng Wu in Scientific Reports (2022)

  10. Article

    Open Access

    Author Correction: Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

    Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen in Scientific Reports (2022)

  11. Article

    Open Access

    Percutaneous iliosacral screw and trans-iliac trans-sacral screw with single C-arm fluoroscope intensifier is a safe treatment for pelvic ring injuries

    To elucidate the accuracy, efficacy, and safety of percutaneous iliosacral screw (ISS) and trans-iliac trans-sacral screw (TITS) insertion using a single C-arm fluoroscopy intensifier. Additionally, the potent...

    Jui-** Chen, **-Jui Tsai, Chun-Yi Su, I.-Chuan Tseng in Scientific Reports (2022)

  12. Article

    Open Access

    Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats

    The endometrium plays a critical role in embryo implantation and pregnancy, and a thin uterus is recognized as a key factor in embryo implantation failure. Umbilical cord mesenchymal stem cells (UC-MSCs) have ...

    Lu Zhang, Ying Li, Yi-Chao Dong, Chun-Yi Guan, Shi Tian, **ao-Dan Lv in Scientific Reports (2022)

  13. Article

    Open Access

    FTY720 in resistant human epidermal growth factor receptor 2-positive breast cancer

    The prognosis of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer has considerably improved. However, no reliable treatment besides anti-HER2 strategies has been available. ...

    Wei-Pang Chung, Wei-Lun Huang, Wei-An Liao, Chun-Hua Hung in Scientific Reports (2022)

  14. Article

    Open Access

    Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

    The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated...

    Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen in Scientific Reports (2021)

  15. Article

    Open Access

    Nationwide registry of glecaprevir plus pibrentasvir in the treatment of HCV in Taiwan

    The study evaluated the real-world treatment outcomes of Glecaprevir/pibrentasvir (GLE/PIB) including effectiveness, safety and healthcare resource utilization based on a nation-wide registry in Taiwan. The Ta...

    Chung-Feng Huang, Hsing-Tao Kuo, Te-Sheng Chang, Ching-Chu Lo in Scientific Reports (2021)

  16. Article

    Open Access

    Survival outcomes of management in metastatic gastric adenocarcinoma patients

    Chemotherapy is generally considered as the main treatment for metastatic gastric adenocarcinoma. The role of gastrectomy for metastatic gastric cancer without obvious symptoms is controversial. The objective ...

    Huang-Ming Hu, Hui-Jen Tsai, Hsiu-Ying Ku, Su-Shun Lo, Yan-Shen Shan in Scientific Reports (2021)

  17. Article

    Open Access

    Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

    The ADJUVANT study reported the comparative superiority of adjuvant gefitinib over chemotherapy in disease-free survival of resected EGFR-mutant stage II–IIIA non-small cell lung cancer (NSCLC). However, not all ...

    Si-Yang Liu, Hua Bao, Qun Wang, Wei-Min Mao, Yedan Chen in Nature Communications (2021)

  18. Article

    Open Access

    A system for reporting and evaluating adverse drug reactions of herbal medicine in Taiwan from 1998 to 2016

    The Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) has systematically documented suspected adverse events from adverse drug reaction (ADR) reports from 1998 (prior to its formal ...

    Hen-Hong Chang, Su-Yin Chiang, Pei-Chun Chen, Chia-Han Tsai in Scientific Reports (2021)

  19. Article

    Open Access

    Wuzi-Yanzong prescription alleviates spermatogenesis disorder induced by heat stress dependent on Akt, NF-κB signaling pathway

    Akt and nuclear factor kappa B (NF-κB) signaling pathways are involved in germ cell apoptosis and inflammation after testicular heat stress (THS). We observed that after THS induced by the exposure of rat test...

    Su-Qin Hu, Dian-Long Liu, Chun-Rui Li, Ya-Hui Xu, Ke Hu, Li-Dan Cui in Scientific Reports (2021)

  20. Article

    Open Access

    Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein

    Oligomerization of Pr55Gag is a critical step of the late stage of the HIV life cycle. It has been known that the binding of IP6, an abundant endogenous cyclitol molecule at the MA domain, has been linked to the ...

    Halilibrahim Ciftci, Hiroshi Tateishi, Kotaro Koiwai, Ryoko Koga in Scientific Reports (2021)

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