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Article
Open AccessPredicting frailty in older adults using vocal biomarkers: a cross-sectional study
Frailty is a common issue in the aging population. Given that frailty syndrome is little discussed in the literature on the aging voice, the current study aims to examine the relationship between frailty and v...
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Article
Open AccessA system for reporting and evaluating adverse drug reactions of herbal medicine in Taiwan from 1998 to 2016
The Taiwan Adverse Drug Reaction Reporting System for Herbal Medicine (TADRRS-HM) has systematically documented suspected adverse events from adverse drug reaction (ADR) reports from 1998 (prior to its formal ...
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Article
Open AccessA systematic identification of anti-inflammatory active components derived from Mu Dan Pi and their applications in inflammatory bowel disease
Mu Dan Pi (MDP), also known as Moutan Cortex Radicis, is a traditional Chinese medicine used to treat autoimmune diseases. However, the impact of MDP and its principal active compounds on inflammatory bowel di...
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Article
Open AccessIdentifying the functions and biomarkers of Codonopsis pilosula and Astragalus membranaceus aqueous extracts in hepatic cells
Homeostasis is a crucial concept used to describe the condition of patients and the roles of herbs in traditional Chinese medicine. Qi-deficiency pattern is one of the conditions when loss of homeostasis and i...
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Article
Open AccessCorrection: Corrigendum: The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren’s syndrome: A Nationwide Population-Based Study
Scientific Reports 5: Article number: 9541; published online: 29 April 2015; updated: 25 May 2017. In this Article, Affiliation 2 is incorrectly listed as ‘Graduate Institute of Clinical Medicine, and Graduate...
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Article
Open AccessAlpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration
It is known that the medicinal herb Alpinia oxyphylla Miq. is widely used as a remedy for diarrhea as well as the symptoms accompanying hypertension and cerebrovascular disorders. Moreover, it has also been re...
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Article
Open AccessTransformation of 5-D itch scale and numerical rating scale in chronic hemodialysis patients
Pruritus is a common and frustrating symptom in hemodialysis (HD) patients and 5-D itch scale is proposed as a reliable measurement of pruritus. However, information regarding 5-D itch scale categories is curr...
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Article
Open AccessTreatment of allergic rhinitis with acupoint herbal plaster: an oligonucleotide chip analysis
Allergic rhinitis is regarded as an imbalanced Th1/Th2 cell-mediated response. The present study used microarray analysis to compare gene expression levels between allergic rhinitis patients before and after a...
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Article
Open AccessValidation of a new simple scale to measure symptoms in heart failure from traditional Chinese medicine view: a cross-sectional questionnaire study
Current clinical practices used to functionally classify heart failure (HF) are time-consuming, expensive, or require complex calculations. This study aimed to design an inquiry list from the perspective of tr...
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Article
Open AccessThe association between arterial stiffness and tongue manifestations of blood stasis in patients with type 2 diabetes
Diabetes mellitus (DM) is a hypercoagulable state and is associated with highly increased risk of vascular complications. In the theory of traditional Chinese medicine (TCM), these vascular complications are c...
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Article
Open AccessModulation of Endothelial Injury Biomarkers by Traditional Chinese Medicine LC in Systemic Lupus Erythematosus Patients Receiving Standard Treatments
LC is an herbal remedy effectively reduced therapeutic dosage of glucocorticoid for systemic lupus erythematosus (SLE) patients in clinical trial (ISRCTN81818883). This translational research examined the impa...
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Article
Open AccessCorrection: Corrigendum: The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren’s syndrome: A Nationwide Population-Based Study
This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIR...
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Article
Open AccessThe Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study
This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIR...
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Article
Open AccessQuantitative assessment of mitochondrial DNA copies from whole genome sequencing
Mitochondrial dysfunction is associated with various aging diseases. The copy number of mtDNA in human cells may therefore be a potential biomarker for diagnostics of aging. Here we propose a new computational...
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Article
Modulation of the cannabinoid receptors by andrographolide attenuates hepatic apoptosis following bile duct ligation in rats with fibrosis
Bile acid-induced apoptosis plays an important role in the pathogenesis of cholestatic liver disease, and its prevention is of therapeutic interest. The aim of this study was to test whether the andrographolid...
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Article
The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes
The accumulation of hydrophobic bile acids plays a role in the induction of apoptosis and necrosis of hepatocytes during cholestasis. Glycochenodeoxycholate acid (GCDC) triggers a rapid oxidative stress respon...
