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Article
Open AccessRapid and efficient ambient temperature X-ray crystal structure determination at Turkish Light Source
High-resolution biomacromolecular structure determination is essential to better understand protein function and dynamics. Serial crystallography is an emerging structural biology technique which has fundament...
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Article
Evaluation of anti-glioma effects of benzothiazoles as efficient apoptosis inducers and DNA cleaving agents
Glioma is the fast-growing, aggressive, and prevalent brain cancer with a great level of morbidity and mortality. Current therapy is usually found insufficient for glioma treatment. In the course of our resear...
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Article
A vitamin D C/D ring-derived compound with cytotoxicity
Study on the biological activity of compounds consisting only of the C/D ring of vitamin D has been very limited. We found that a synthetic C/D ring alcohol 3 reduced the viability of HeLa cells. Compound 3 was m...
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Article
Open AccessStructural insight into host plasma membrane association and assembly of HIV-1 matrix protein
Oligomerization of Pr55Gag is a critical step of the late stage of the HIV life cycle. It has been known that the binding of IP6, an abundant endogenous cyclitol molecule at the MA domain, has been linked to the ...
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Article
Open AccessSe-SAD serial femtosecond crystallography datasets from selenobiotinyl-streptavidin
We provide a detailed description of selenobiotinyl-streptavidin (Se-B SA) co-crystal datasets recorded using the Coherent X-ray Imaging (CXI) instrument at the Linac Coherent Light Source (LCLS) for selenium ...
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Article
Open AccessSelenium single-wavelength anomalous diffraction de novo phasing using an X-ray-free electron laser
Structural information about biological macromolecules near the atomic scale provides important insight into the functions of these molecules. To date, X-ray crystallography has been the predominant method use...
