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Article
Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib‐sensitive and bortezomib‐resistant multiple myeloma phenotypes
Multiple myeloma (MM) is an incurable hematological malignancy with increasing incidence and mortality rates, with a worldwide incidence of 160,000 cases per year. Currently approved treatments, including bort...
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Article
Open AccessRelationship between serum cortisol levels, stereotypies, and the presence of autism spectrum disorder in patients with severe intellectual disability
Stereotypies are one of the diagnostic criteria for autism spectrum disorder (ASD) and are common to both ASD and intellectual disability (ID). Previous studies have been inconclusive, with some showing a posi...
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Article
Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells
The anti-allergic drug tranilast (TNL) reportedly exhibits inhibitory activity against epithelial-mesenchymal transition (EMT) at high concentrations. Herein, we synthesized a new hybrid molecule, tyrosine-con...
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Article
A vitamin D C/D ring-derived compound with cytotoxicity
Study on the biological activity of compounds consisting only of the C/D ring of vitamin D has been very limited. We found that a synthetic C/D ring alcohol 3 reduced the viability of HeLa cells. Compound 3 was m...
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Article
Open AccessStructural insight into host plasma membrane association and assembly of HIV-1 matrix protein
Oligomerization of Pr55Gag is a critical step of the late stage of the HIV life cycle. It has been known that the binding of IP6, an abundant endogenous cyclitol molecule at the MA domain, has been linked to the ...
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Article
Open AccessDonepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia
Microglia are resident innate immune cells which release many factors including proinflammatory cytokines or nitric oxide (NO) when they are activated in response to immunological stimuli. Pathophysiology of A...
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Article
Open AccessA clue to unprecedented strategy to HIV eradication: “Lock-in and apoptosis”
Despite the development of antiretroviral therapy against HIV, eradication of the virus from the body, as a means to a cure, remains in progress. A “kick and kill” strategy proposes “kick” of the latent HIV to...
