142 Result(s)

Article

DSE inhibits melanoma progression by regulating tumor immune cell infiltration and VCAN

Dermatan sulfate epimerase (DSE) is a C5 epiminase that plays a key role in converting chondroitin sulfate into dermal sulfate. DSE is often upregulated during carcinogenesis of some types of cancer and can re...

Lin **a, Maoxiao Feng, Yidan Ren, **aodong Hao, Qinlian Jiao… in Cell Death Discovery (2023)

Article

Antler stem cell exosomes alleviate pulmonary fibrosis via inhibiting recruitment of monocyte macrophage, rather than polarization of M2 macrophages in mice

Pulmonary fibrosis (PF), a chronic interstitial lung disease, is characterized by over-abundant deposition of extracellular matrix consisting mainly of collagen I. In previous studies, we demonstrated that dee...

Guokun Zhang, Liyan Shi, Ji** Li, Shengnan Wang, **g Ren… in Cell Death Discovery (2023)

Article

In vitro CRISPR screening uncovers CRTC3 as a regulator of IFN-γ-induced ferroptosis of hepatocellular carcinoma

Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that ...

Li Li, Tao **ng, Yiran Chen, Weiran Xu, Bo Fan, Gaoda Ju, **g Zhao… in Cell Death Discovery (2023)

Article

SCARB1 in extracellular vesicles promotes NPC metastasis by co-regulating M1 and M2 macrophage function

Distant metastasis is currently the main factor affecting the prognosis of nasopharyngeal carcinoma (NPC), and understanding the mechanisms of metastasis and identifying reliable therapeutic targets are critic...

Wenhui Chen, Lili Bao, Qianqian Ren, Zixiang Zhang, Lu Yi, Wei Lei… in Cell Death Discovery (2023)

Article

Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement

Hepatocellular carcinoma (HCC), the most prevalent type of aggressive liver cancer, accounts for the majority of liver cancer diagnoses and fatalities. Despite recent advancements in HCC treatment, it remains ...

Huijie Jia, Pengkun Wei, Shijie Zhou, Yuanyuan Hu, Chun**g Zhang… in Cell Death Discovery (2023)

Article

ALKBH5 promotes hypopharyngeal squamous cell carcinoma apoptosis by targeting TLR2 in a YTHDF1/IGF2BP2-mediated manner

Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most aggressive cancers and is notorious for its extremely poor prognosis. However, very few molecular biological studies have been performed. As a ...

**g Ye, Yuting Wu, Yao Chen, Yiyue Ren, **aohua Jiang… in Cell Death Discovery (2023)

Article

Cezanne promoted autophagy through PIK3C3 stabilization and PIK3C2A transcription in lung adenocarcinoma

Osimertinib is a promising approved third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treating patients with lung adenocarcinoma (LUAD) harboring EGFR-activating mutati...

Yadong Wang, Jiahao Li, Haotian Zheng, Kai Wang, **aoyang Ren… in Cell Death Discovery (2023)

Article

Nanoparticles carrying paclitaxel and anti-miR-221 for breast cancer therapy triggered by ultrasound

Nanomaterials have been well demonstrated to have the potential to be used for tumor cell-targeted drug delivery. Targeted inhibition of miR-221 was proved to promote the sensitivity of triple genitive breast ...

Libo Zhang, Zhen Ren, **hui Lü, **nhai Mo, Jie Lin, Ya Li… in Cell Death Discovery (2023)

Article

Ionizing radiation triggers mitophagy to enhance DNA damage in cancer cells

Radiotherapy is an important cancer treatment strategy that causes DNA damage in tumor cells either directly or indirectly. Autophagy is a physiological process linked to DNA damage. Mitophagy is a form of aut...

Yanxian Ren, Pengfei Yang, Chenghao Li, Wen-an Wang, Tianyi Zhang… in Cell Death Discovery (2023)

Article

Lipid droplets: a cellular organelle vital in cancer cells

Lipid droplets (LDs) are cellular organelles comprising a core of neutral lipids (glycerides, sterols) encased within a single phospholipid membrane, responsible for storing surplus lipids and furnishing cellu...

Yi **, Yanjie Tan, Jian Wu, Zhuqing Ren in Cell Death Discovery (2023)

Article

LncRNA miR663AHG represses the development of colon cancer in a miR663a-dependent manner

The MIR663AHG gene encodes both miR663AHG and miR663a. While miR663a contributes to the defense of host cells against inflammation and inhibits colon cancer development, the biological function of lncRNA miR663AH...

Hongfan Yuan, Qianwen Ren, Yantao Du, Yuwan Ma, Liankun Gu… in Cell Death Discovery (2023)

Article

Ferroptosis and the bidirectional regulatory factor p53

Ferroptosis is a type of regulated cell death characterized by iron-mediated lipid peroxidation, in contrast with apoptosis, autophagy, and necrosis. It can be triggered by many pathological processes, includi...

Ren Xu, Wanning Wang, Wenlong Zhang in Cell Death Discovery (2023)

Article

Correction to: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

Ronnie Ren Jie Low, Ka Yee Fung, Hugh Gao, Adele Preaudet… in Cell Death & Differentiation (2023)

Article

S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer

Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT, and mesenchymal states, each of which is associated with cancer progression, invasive capabilities, and ultimately,...

Ronnie Ren Jie Low, Ka Yee Fung, Hugh Gao, Adele Preaudet… in Cell Death & Differentiation (2023)

Article

Let-7b-5p inhibits breast cancer cell growth and metastasis via repression of hexokinase 2-mediated aerobic glycolysis

Hexokinase 2 (HK2), a critical rate-limiting enzyme in the glycolytic pathway catalyzing hexose phosphorylation, is overexpressed in multiple human cancers and associated with poor clinicopathological features...

Ling Li, **ujuan Zhang, Yanni Lin, **nxin Ren, Tian **e, **g Lin… in Cell Death Discovery (2023)

Article

Correction to: NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis

CircRNAs play crucial roles in various malignancies via an increasing number of reported regulatory mechanisms, including the classic sponging mechanism between circRNAs and micro RNAs (miRNAs). We performed b...

**gbing Lou, Hongliang Zhang, Qingshan Huang, Chenglong Chen… in Cell Death Discovery (2023)

Article

Regulatory T cells (Tregs) in liver fibrosis

The ability of the human liver to both synthesize extracellular matrix(ECM), as well as regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver injury stimulates fibrogenesis i...

Ke-jia Wu, Qu-fei Qian, **-ren Zhou, Dong-lin Sun, Yun-fei Duan… in Cell Death Discovery (2023)

Article

NSUN2 alleviates doxorubicin-induced myocardial injury through Nrf2-mediated antioxidant stress

Doxorubicin (DOX) is a commonly used antitumor drug, but its application has been limited because of its strong cardiac damage. This study aims to explore the role of NSUN2 in DOX-induced heart injury. C57BL/6...

Yi Wang, Yuxin Zan, Yingying Huang, **aoyun Peng, Shinan Ma, Ji Ren… in Cell Death Discovery (2023)

Article

Sirtuin 4 activates autophagy and inhibits tumorigenesis by upregulating the p53 signaling pathway

The role of autophagy in cancer is context-dependent. In the present study, we aimed to investigate the regulator and underlying mechanism of autophagy. We found that a sirtuin (SIRT) family member, SIRT4, was...

Juan Li, Hanxiang Zhan, Yidan Ren, Maoxiao Feng, Qin Wang… in Cell Death & Differentiation (2023)