36 Result(s)
within
Article
Joel S. Bader
English
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Article
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design
A milestone in biology was reached in 2010, with the production of a viable bacterium with a genome that had been reassembled artificially from synthetic DNA segments. Now Jef Boeke and colleagues report the p...
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Angiogenesis-Associated Crosstalk Between Collagens, CXC Chemokines, and Thrombospondin Domain-Containing Proteins
Excessive vascularization is a hallmark of many diseases including cancer, rheumatoid arthritis, diabetic nephropathy, pathologic obesity, age-related macular degeneration, and asthma. Compounds that inhibit a...
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Grand network convergence
A report of the Systems Biology: Networks meeting, Cold Spring Harbor, USA, 22-26 March 2011.
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Open AccessResolving the structure of interactomes with hierarchical agglomerative clustering
Graphs provide a natural framework for visualizing and analyzing networks of many types, including biological networks. Network clustering is a valuable approach for summarizing the structure in large networks...
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Open AccessPredicting functional associations from metabolism using bi-partite network algorithms
Metabolic reconstructions contain detailed information about metabolic enzymes and their reactants and products. These networks can be used to infer functional associations between metabolic enzymes. Many meth...
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Open AccessNeMo: Network Module identification in Cytoscape
As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathways. Previous studies have shown that densel...
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Open AccessAnalytical approximations for the amplitude and period of a relaxation oscillator
Analysis and design of complex systems benefit from mathematically tractable models, which are often derived by approximating a nonlinear system with an effective equivalent linear system. Biological oscillato...
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Human Proteinpedia enables sharing of human protein data
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Correction: Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
Nature 437, 376–380 (2005) In this paper, the second name of Chun Heen Ho was misspelled as He. In the earlier Corrigendum (Nature 439, 502; 2006) the surnames of Stephen K. Hutchison and Brian C. Godwin were ...
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Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets
We present the first analysis of the human proteome with regard to interactions between proteins. We also compare the human interactome with the available interaction datasets from yeast (Saccharomyces cerevisiae
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Correction: Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors
Nature 437, 376–380 (2005)10.1038/nature03959 The following were omitted from the original author listing: Alex de Winter, James Drake, Robin Forte, Steve Hutchinson, William L. Lee, Michael Reifler and David ...
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Open AccessGenetic interaction motif finding by expectation maximization – a novel statistical model for inferring gene modules from synthetic lethality
Synthetic lethality experiments identify pairs of genes with complementary function. More direct functional associations (for example greater probability of membership in a single protein complex) may be infer...
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Open AccessCommensurate distances and similar motifs in genetic congruence and protein interaction networks in yeast
In a genetic interaction, the phenotype of a double mutant differs from the combined phenotypes of the underlying single mutants. When the single mutants have no growth defect, but the double mutant is lethal ...
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Open AccessGenome sequencing in microfabricated high-density picolitre reactors
The proliferation of large-scale DNA-sequencing projects in recent years has driven a search for alternative methods to reduce time and cost. Here we describe a scalable, highly parallel sequencing system with...
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Gaining confidence in high-throughput protein interaction networks
Although genome-scale technologies have benefited from statistical measures of data quality, extracting biologically relevant pathways from high-throughput proteomics data remains a challenge. Here we develop ...
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DNA Pooling: a tool for large-scale association studies
DNA pooling is an effective way of reducing the cost of genoty** in large-scale association studies.
DNA...
