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Open AccessImmunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals
The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine such variable outcomes remain unres...
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Article
Open AccessOphthatome™: an integrated knowledgebase of ophthalmic diseases for translating vision research into the clinic
Medical big data analytics has revolutionized the human healthcare system by introducing processes that facilitate rationale clinical decision making, predictive or prognostic modelling of the disease progress...
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Article
Open AccessIntegrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Gallbladder cancer (GBC) is an aggressive gastrointestinal malignancy with no approved targeted therapy. Here, we analyze exomes (n = 160), transcriptomes (n = 115), and low pass whole genomes (n = 146) from 167 ...
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Open AccessA cancer vaccine approach for personalized treatment of Lynch Syndrome
Lynch syndrome (LS) is a cancer predisposition disorder wherein patients have a 70–80% lifetime risk of develo** colorectal cancers (CRC). Finding germline mutations in predisposing genes allows for risk ass...
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Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two
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Comprehensive genomic analysis of malignant pleural mesothelioma identifies recurrent mutations, gene fusions and splicing alterations
Raphael Bueno, Eric Stawiski, Somasekar Seshagiri and colleagues present a comprehensive genomic analysis of malignant pleural mesothelioma. They identify four distinct molecular subtypes using RNA-seq data an...
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Gaining confidence in high-throughput protein interaction networks
Although genome-scale technologies have benefited from statistical measures of data quality, extracting biologically relevant pathways from high-throughput proteomics data remains a challenge. Here we develop ...
