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  1. Article

    Open Access

    High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors

    DNA copy number alterations are frequently observed in ovarian cancer, but it remains a challenge to identify the most relevant alterations and the specific causal genes in those regions.

    Peter M Haverty, Lawrence S Hon, Joshua S Kaminker, John Chant… in BMC Medical Genomics (2009)

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  2. No Access

    Article

    Gaining confidence in high-throughput protein interaction networks

    Although genome-scale technologies have benefited from statistical measures of data quality, extracting biologically relevant pathways from high-throughput proteomics data remains a challenge. Here we develop ...

    Joel S Bader, Amitabha Chaudhuri, Jonathan M Rothberg, John Chant in Nature Biotechnology (2004)

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    Article

    BUD2 encodes a GTPase-activating protein for Budl/Rsrl necessary for proper bud-site selection in yeast

    CELLS of the budding yeast Saccharomyces cerevisiae bud at either axial or bipolar sites depending on their cell type1. Bud-site selec-tion directs both cell polarity and the cytoskeletal orientation dur-ing budd...

    Hay-Oak Park, John Chant, Ira Herskowitz in Nature (1993)

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    Chapter

    The New Theory of Financial Intermediation

    Financial institutions that borrow from ultimate lenders and lend to ultimate borrowers are prominent features of any modern economy, yet present an apparent paradox. The lenders could lend directly to the bor...

    John Chant in Current Issues in Financial and Monetary Economics (1992)