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Article
Magnetic resonance galactography for a patient with nipple discharge
A new method of galactography using magnetic resonance imaging for a patient with nipple discharge is developed. The method is as follows; coronal T1-weight images are obtained after an injection of contrast m...
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Article
Surgical treatment of hepatic metastases from breast cancer
We have performed a retrospective study to evaluate whether surgical treatment is beneficial in patients with hepatic metastases from breast cancer. Between September 1985 and September 1998, 25 patients with ...
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Article
Surgery for ductal carcinoma in Situ
Ductal carcinomasin situ (DCIS) are sometimes treated too aggressively by surgery. We discuss minimal invasive surgery for DCIS on the basis of our experience at the Cancer Institute Hospitel in Tokyo.
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Chapter
Continuous GPS Array and Present-day Crustal Deformation of Japan
A GPS array with about 1,000 permanent stations is under operation in Japan. The GPS array revealed coseismic deformations associated with large earthquakes and ongoing secular deformation in the Japanese isla...
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Article
Open AccessUnexpected increase in the bone marrow toxicity of mitomycin C (MMC)
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Article
Correlation of allelic losses and clinicopathological factors in 504 primary breast cancers
We have defined 18 chromosomal regions in which allelic losses were frequent among breast cancers. We examined whether specific allelic losses might correlate with any clinicopathological factors.
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Article
Crustal deformation around the northern and central Itoigawa-Shizuoka Tectonic Line
We established a dense permanent GPS array around the northern and central Itoigawa-Shizuoka Tectonic Line (ISTL) in order to study loading processes of inland active faults. 1–4 years observation has revealed...
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Article
What is the predictor for invasion in non-palpable breast cancer with microcalcifications?
To assess the presence of invasion in non-palpable breast cancer with microcarcifications.
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Article
Clinical study on the metastasis to the eyes from breast cancer
In our hospital, 24 patients who underwent surgery for breast cancer during 1980 to 2001 were diagnosed with metastasis to the eye. Metastasis to the choroid was found most frequently, making the choroid the m...
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Protocol
Nuclear Reprogramming
Nuclear reprogramming is an intriguing phenomenon, in which specialized somatic cells reacquire pluripotency through the global resetting of epigenetic modifications without changes occurring to their nuclear ...
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Protocol
Nuclear Reprogramming of Somatic Nucleus Hybridized With Embryonic Stem Cells by Electrofusion
Cell fusion is a powerful tool for understanding the molecular mechanisms of epigenetic reprogramming. In hybrid cells of somatic cells and pluripotential stem cells, including embryonic stem (ES) and embryoni...
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Protocol
Epigenetic Reprogramming of Somatic Genomes by Electrofusion With Embryonic Stem Cells
Cell fusion is an approach for combining genetic and epigenetic information between two different types of cells. Electrofusion for generating hybrid cells between mouse embryonic stem cells and somatic cells,...
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Article
Targeted chromosome elimination from ES-somatic hybrid cells
To engineer a stem cell genome, we developed a technology for targeted elimination of chromosomes from mouse embryonic stem (ES)–somatic hybrid cells. Here we demonstrate the use of a universal chromosome elim...
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Article
Target chromosomes of inducible deletion by a Cre/inverted loxP system in mouse embryonic stem cells
Chromosomal deletions are widely involved in serious genetic diseases and in the pathogenesis of cancers. These deletions often generate loss of heterozygosity (LOH) of one of the alleles of a tumor suppressor...
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Article
Familiarity and Prudence of the Japanese Public with Research into Induced Pluripotent Stem Cells, and Their Desire for its Proper Regulation
The lack of knowledge of current public attitudes towards basic research into induced pluripotent stem cells (iPSCs) is a serious problem when considering appropriate ways of governance regarding research and ...
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Book
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Chapter
Cell Fusion-Mediated Nuclear Reprogramming of Somatic Cells
Epigenetic reprogramming of nuclei from differentiated to pluripotent state can be induced by three experimental approaches: nuclear transfer, cell fusion, and transduction of transcription factors. In cell fu...
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Protocol
Generation of Induced Pluripotent Stem Cells from Human Amnion Cells
Induced pluripotent stem (iPS) cells have been generated through nuclear reprogramming of somatic cells via retrovirus- or lentivirus-mediated transduction of exogenous reprogramming factors OCT3/4, SOX2, KLF4, a...
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Chapter
Epilogue
Recent fascinating developments in the interwoven areas of molecular biology, biochemistry, and biomedicine are starting to provide explanations for many complicated “phenomena,” enabling them to be broken dow...
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Article
Open AccessGenomic organization, evolution, and expression of photoprotein and opsin genes in Mnemiopsis leidyi: a new view of ctenophore photocytes
Calcium-activated photoproteins are luciferase variants found in photocyte cells of bioluminescent jellyfish (Phylum Cnidaria) and comb jellies (Phylum Ctenophora). The complete genomic sequence from the cteno...
