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Article
Comparison of mycobacterial interspersed repetitive unit-variable number tandem repeat and IS6110-RFLP methods in identifying epidemiological links in patients with tuberculosis in Northwest of Iran
In recent years in spite of medical advancement, tuberculosis remains as a worldwide health problem. Therefore, identifying the source of transmission of infection is necessary for decreasing of tuberculosis (...
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Viral infections in patients with acute respiratory infection in Northwest of Iran
Acute respiratory infection (ARI) is one of the main causes of morbidity and mortality all around the world. The aim of this study was to determine the frequency, mortality and association with clinical entiti...
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Article
Prevalence and molecular characterization of class 1 integrons among clinical isolates of Pseudomonas aeruginosa in Northwest of Iran
Integrons are introduced as the most common mechanism for resistance gene dissemination in Pseudomonas aeruginosa.
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Article
Lactobacillus plantarum as a Probiotic Potential from Kouzeh Cheese (Traditional Iranian Cheese) and Its Antimicrobial Activity
The aim of this study is to isolate and identify Lactobacillus plantarum isolates from traditional cheese, Kouzeh, and evaluate their antimicrobial activity against some food pathogens. In total, 56 lactic aci...
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Article
Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite
Apoptosis of infected host macrophages by Leishmania spp. is mainly addressed as one of the survival mechanisms of the parasite. However, there is no eligible data about whether tumor suppressor p53 could induce ...
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Article
Synthesis of azo dyes possessing N-heterocycles and evaluation of their anticancer and antibacterial properties
A series of 4-(1-azolyl)aniline derivatives (azole = imidazole, benzimidazole, pyrazole, 3-methylpyrazole, and 4-methylpyrazole) underwent diazotization reaction by NaNO2/HCl. The diazonium salts were consequentl...
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Article
Open AccessRaising concerns about the Sepsis-3 definitions
The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in th...
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Article
Metal nanoparticles and consequences on multi-drug resistant bacteria: reviving their role
The most paramount challenge faced globally by the physicians is to treat the infections caused by nosocomial multi-drug resistant microorganisms. These bacteria are endowed with unique efflux pumps, which are...
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Article
Laboratory Cross-Contamination of Mycobacterium tuberculosis: A Systematic Review and Meta-analysis
Microbiological cultures are the mainstay of the diagnosis of tuberculosis (TB). False-positive TB results lead to significant unnecessary therapeutic and economic burden and are frequently caused by laborator...
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Article
Non-alcoholic fatty liver diseases: from role of gut microbiota to microbial-based therapies
Non-alcoholic fatty liver disease (NAFLD) is the well-known disease of the liver in adults and children throughout the world. The main manifestations related to NAFLD are an unusual storage of lipid in hepatoc...
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Article
MicroRNAs, DNA damage response and ageing
Ageing is a multifactorial and integrated gradual deterioration affecting the most of biological process of cells. MiRNAs are differentially expressed in the cellular senescence and play important role in regu...
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Article
Comparative study on the microbial quality in the swimming pools disinfected by the ozone-chlorine and chlorine processes in Tabriz, Iran
Applying a desirable disinfestation process is necessary to control the pathogenic microorganisms in the swimming pools and prevent both dermal and intestinal effects. Therefore, the present study was conducte...
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Article
Thiazolidine-2-Thione and 2-Imino-1,3-Dithiolane Derivatives: Synthesis and Evaluation of Antimicrobial Activity
The emergence of antibiotic resistance is one of the most important public health concerns in the world. To solve this major problem, a series of antimicrobial compounds have been synthesized and tested agains...
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Article
Open AccessEffect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: a double blind placebo controlled randomized clinical trial
Alterations in the gut microbiome (dysbiosis) has been associated with increased microbial translocation, leading to chronic inflammation in coronary artery disease (CAD). It has been proposed that modulation ...
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Article
Novel Strategies to Combat Bacterial Biofilms
Biofilms are considered as a severe problem in the treatment of bacterial infections; their development causes some noticeable resistance to antibacterial agents. Biofilms are responsible for at least two-thir...
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Article
Open AccessRole of CRISPR-Cas system on antibiotic resistance patterns of Enterococcus faecalis
Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas systems are one of the factors which can contribute to limiting the development and evolution of antibiotic resistance in bacteria. There a...
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Article
Effects of Gentamicin-Loaded Chitosan-ZnO Nanocomposite on Quorum-Sensing Regulation of Pseudomonas Aeruginosa
Cell density-based intercellular signaling mechanism is known as Quorum sensing (QS); it serves a significant role in regulating the pathogenic factors. The objective of the present study was to assess the inf...
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Article
Preparation, characterization, and antibacterial properties of hybrid nanofibrous scaffolds for cutaneous tissue engineering
Since polymeric nanofibrous scaffolds have been widely used in tissue regeneration, the risk of bacterial infections should not be neglected. In the present work, poly-caprolactone-silk fibroin-soluble eggshel...
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Article
Calix[4]arene-based thiosemicarbazide Schiff-base ligand and its transition metal complexes: synthesis and biological assessment
Thiosemicarbazides have the capability of killing the cancerous tumor cells and inhibit the growth of bacteria and fungus. Here, we designed and synthesized a calix[4]arene-based thiosemicarbazone Schiff-base ...
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Open AccessEvaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals
The purpose of the current study was to evaluate the phenotypic and genotypic patterns of aminoglycoside resistance among the Gram-negative bacteria (GNB) isolates collected from pediatric and general hospital...