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Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains...
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Replication-competent HIV-1 in human alveolar macrophages and monocytes despite nucleotide pools with elevated dUTP
BackgroundAlthough CD4 + memory T cells are considered the primary latent reservoir for HIV-1, replication competent HIV has been detected in tissue...
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Pseudotyped Viruses
Pseudotyped viruses have been constructed for many viruses. They can mimic the authentic virus and have many advantages compared to authentic...
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Organ-specific genome diversity of replication-competent SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not always confined to the respiratory system, as it impacts people on a...
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Design of Replication-Competent VSV- and Ervebo-Vectored Vaccines Against SARS-CoV-2
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health emergency....
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A qPCR-Based Method for Quantification of Replication Competent Adenovirus (RCA) in Conditionally Replicating Oncolytic Adenoviruses
Production of conditionally replicating adenoviruses may unfortunately generate undesired replication-competent adenovirus (RCA) which raises safety...
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A single dose of replication-competent VSV-vectored vaccine expressing SARS-CoV-2 S1 protects against virus replication in a hamster model of severe COVID-19
The development of effective countermeasures against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the agent responsible for the...
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Pseudotyped Viruses for Orthohantavirus
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense,...
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Analysis of PERV-C superinfection resistance using HA-tagged viruses
BackgroundUsing pigs as organ donors has advanced xenotransplantation to the point that it is almost ready for clinical use. However, there is still...
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Evolution of Viruses in Immunized Populations of Vertebrates
AbstractScientists have described thousands of species of viruses, many of which are pathogens of vertebrates. Given that vertebrates have their...
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Interactions between avian viruses and skin in farm birds
This article reviews the avian viruses that infect the skin of domestic farm birds of primary economic importance: chicken, duck, turkey, and goose....
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Replicating-Competent VSV-Vectored Pseudotyped Viruses
Vesicular stomatitis virus (VSV) is prototype virus in the family of Rhabdoviridae. Reverse genetic platform has enabled the genetic manipulation of...
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Pseudotyped Viruses for Marburgvirus and Ebolavirus
Marburg virus (MARV) and Ebola virus (EBOV) of the Filoviridae family are the most lethal viruses in terms of mortality rate. However, the...
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Pseudotyped Viruses for Influenza
We have developed an influenza hemagglutinin (HA) pseudotype (PV) library encompassing all influenza A (IAV) subtypes from HA1-HA18, influenza B...
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Type I Interferon: Monkeypox/Mpox Viruses Achilles Heel?
Poxviruses are notorious for having acquired/evolved numerous genes to counteract host innate immunity. Chordopoxviruses have acquired/evolved at...
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Self-Replicating RNA Derived from the Genomes of Positive-Strand RNA Viruses
Self-replicating RNA derived from the genomes of positive-strand RNA viruses represents a powerful tool for both molecular studies on virus biology...
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Metagenomic and Molecular Detection of Novel Fecal Viruses in Free-Ranging Agile Wallabies
The agile wallaby ( Notamacropus agilis ) is one of the most abundant marsupial species in northern Queensland and a competent host for the zoonotic...
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Simultaneous monitoring of eight human respiratory viruses including SARS-CoV-2 using liquid chromatography-tandem mass spectrometry
Diagnosis of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has primarily been achieved using reverse transcriptase...
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Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy
Oncolytic viruses (OVs) represent a novel class of cancer immunotherapy agents that preferentially infect and kill cancer cells and promote...
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Isolation and evaluation of antiviral plant compounds against respiratory disease-causing viruses: a review
Influenza viruses are major concern worldwide due to their fast ability to spread, and causing the respiratory illness of varying severity. The rate...
