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Evaluation of machine learning-based classification of clinical impairment and prediction of clinical worsening in multiple sclerosis
BackgroundRobust predictive models of clinical impairment and worsening in multiple sclerosis (MS) are needed to identify patients at risk and...
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Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy
BackgroundWhile many women with rheumatoid arthritis (RA) improve during pregnancy and others worsen, there are no biomarkers to predict this...
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Risk factors of worsening kidney function and mortality in patients with renal vein thrombosis: a retrospective study
BackgroundThe outcome of renal vein thrombosis, in particular as for the long-term impact on kidney function, is not fully known. We aimed to...
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Detecting Worsening
This chapter discusses the criteria for deterioration, the art of recognizing deterioration and what causes to consider in a number of key diseases....
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Uplifts and hassles are related to worsening in chronic fatigue syndrome: a prospective study
BackgroundLimited published data suggests that absence of uplifts (minor pleasant events) is associated with clinical worsening in patients with...
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A prediction model for worsening diabetic retinopathy after panretinal photocoagulation
BackgroundAs one of the severe complications of diabetes mellitus, diabetic retinopathy (DR) is the leading cause of blindness in the working age...
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Case 48. Unusual Cause of Worsening AHI on CPAP Download
Patients who present with increased residual apnea-hypopnea index (AHI) on their positive airway pressure (PAP) download should be carefully assessed...
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Associations between cooking fuel use, its transitions, and worsening sensory impairments among Chinese middle-aged and older adults: a cohort study
BackgroundThis study aimed to explore the associations between household air pollution (HAP), measured by cooking fuel use, sensory impairments (SI),...
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A deep learning model incorporating spatial and temporal information successfully detects visual field worsening using a consensus based approach
Glaucoma is a leading cause of irreversible blindness, and its worsening is most often monitored with visual field (VF) testing. Deep learning models...
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Functional and structural brain MRI changes associated with cognitive worsening in multiple sclerosis: a 3-year longitudinal study
BackgroundHeterogeneous processes may contribute to cognitive impairment in multiple sclerosis (MS).
ObjectiveTo apply a longitudinal...
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Use of Immune Profiling Panel to assess the immune response of septic patients for prediction of worsening as a composite endpoint
Sepsis induces intense, dynamic and heterogeneous host response modulations. Despite improvement of patient management, the risk of mortality and...
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Association between triglyceride glucose index and worsening heart failure in significant secondary mitral regurgitation following percutaneous coronary intervention
BackgroundThe triglyceride glucose (TyG) index is an alternative to insulin resistance (IR) as an early indicator of worsening heart failure (HF)....
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Brain MRI activity during the year before pregnancy can predict long-term clinical worsening in patients with Multiple Sclerosis
BackgroundPregnancy has been observed to reduce the frequency of relapses in Multiple Sclerosis (MS) patients, but the relapse risk tends to increase...
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Sudden Neurologic Worsening in the Postoperative Patient
Many neurosurgical patients are brought to the Intensive Care Unit (ICU) for close monitoring in the acute postoperative period, and for good reason:...
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A 6-month longitudinal study on worsening of Parkinson’s disease during the COVID-19 pandemic
Further studies are required to investigate the impact of the COVID-19 pandemic on Parkinson’s disease (PD) progression. This study investigated the...
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Association of OCT and OCT angiography measures with the development and worsening of diabetic retinopathy in type 2 diabetes
ObjectiveTo assess if optical coherence tomography (OCT) and OCT angiography (OCTA) measures are associated with the development and worsening of...
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Development and validation of a community acquired sepsis-worsening score in the adult emergency department: a prospective cohort: the CASC score
BackgroundSepsis is a leading cause of death and serious illness that requires early recognition and therapeutic management to improve survival. The...
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Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis
Limited studies have been conducted to identify and validate multiple sclerosis (MS) genetic loci associated with disability progression. We aimed to...
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Treatment Patterns, Outcomes, and Persistence to Newly Started Heart Failure Medications in Patients with Worsening Heart Failure: A Cohort Study from the United States and Germany
BackgroundData are limited regarding guideline-directed medical therapy (GDMT) treatment patterns in patients with worsening heart failure (HF).
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