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Vesicular glutamate transporters are H+-anion exchangers that operate at variable stoichiometry
Vesicular glutamate transporters accumulate glutamate in synaptic vesicles, where they also function as a major Cl - efflux pathway. Here we combine...
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Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease
The Excitatory Amino Acid Transporter 2 (EAAT2) accounts for 80% of brain glutamate clearance and is mainly expressed in astrocytic perisynaptic...
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Glutamate secretion by embryonic stem cells as an autocrine signal to promote proliferation
Glutamate, the major excitatory neurotransmitter in the central nervous system, has also been found to play a role in embryonic stem (ES) cells....
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Inhibition of the Vesicular Glutamate Transporter (VGLUT) with Congo Red Analogs: New Binding Insights
AbstractThe vesicular glutamate transporter (VGLUT) facilitates the uptake of glutamate (Glu) into neuronal vesicles. VGLUT has not yet been fully...
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Inhibition of Vesicular Glutamate Transporters (VGLUTs) with Chicago Sky Blue 6B Before Focal Cerebral Ischemia Offers Neuroprotection
Brain ischemia is one of the leading causes of death and long-term disability in the world. Interruption of the blood supply to the brain is a direct...
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Whole Endosome Recording of Vesicular Neurotransmitter Transporter Currents
The analysis of organellar membrane transportersMembrane transporters presents many technical problems. In general, their activity depends on a H+...
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Nemacol is a small molecule inhibitor of C. elegans vesicular acetylcholine transporter with anthelmintic potential
Nematode parasites of humans and livestock pose a significant burden to human health, economic development, and food security. Anthelmintic drug...
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Evidence for transporter-mediated uptake of environmental l-glutamate in a freshwater sponge, Ephydatia muelleri
The freshwater sponge, Ephydatia muelleri, lacks a nervous or endocrine system and yet it exhibits a coordinated whole-body action known as a...
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MarÃa Teresa Miras Portugal: a pioneer for vesicular nucleotide storage
Chromaffin granules are secretory granules present in adrenal medulla chromaffin cells. They contain high contents of catecholamines and nucleotides...
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GluN2A- and GluN2B-immunoreactive type I cells attached to vesicular glutamate transporter 2-immunoreactive afferent nerve terminals of the rat carotid body
We previously reported the immunoreactivity for the vesicular glutamate transporter 2 (VGLUT2) in afferent nerve terminals attached to chemoreceptor...
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GPR55 is expressed in glutamate neurons and functionally modulates drug taking and seeking in rats and mice
G protein-coupled receptor 55 (GPR55) has been thought to be a putative cannabinoid receptor. However, little is known about its functional role in...
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Pharmacological Role of Glutamate Transporters in Substance Use Disorders
Substance use disorders (SUD) represent a public health crisis worldwide. The development of effective pharmacotherapeutics to treat drug abuse and...
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Molecular, Structural, Functional, and Pharmacological Sites for Vesicular Glutamate Transporter Regulation
Vesicular glutamate transporters (VGLUTs) control quantal size of glutamatergic transmission and have been the center of numerous studies over the...
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Silencing the Output of Cerebellar Neurons Using Cell Type-Specific Genetic Deletion of Vesicular GABA and Glutamate Transporters
Neurons are distinguished from other cell types by their inherent properties such as electrical excitability and their ability to rapidly communicate...
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Opponent vesicular transporters regulate the strength of glutamatergic neurotransmission in a C. elegans sensory circuit
At chemical synapses, neurotransmitters are packaged into synaptic vesicles that release their contents in response to depolarization. Despite its...
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Structure and inhibition of the human lysosomal transporter Sialin
Sialin, a member of the solute carrier 17 (SLC17) transporter family, is unique in its ability to transport not only sialic acid using a pH-driven...
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Glutamate
Glutamate is the major excitatory neurotransmitter in the brain and is an essential component of the neurochemical architecture of the central...
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Dopamine and vesicular monoamine transport loss supports incidental Lewy body disease as preclinical idiopathic Parkinson
Incidental Lewy body disease (ILBD) is a neuropathological diagnosis of brains with Lewy bodies without clinical neuropsychiatric symptoms....
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Meta-analysis and systematic review of vesicular monoamine transporter (VMAT-2) inhibitors in schizophrenia and psychosis
RationaleDopamine antagonists induce dopamine receptor supersensitivity. This may manifest in late-appearing movement disorders (tardive dyskinesia...
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Analysis of Synaptic Glutamate Clearance as a Possible Indicator of Synaptic Health in the Degenerating Rodent Brain
Neurodegeneration may present multiple challenges when one tries to quantify the astrocytic contribution to synaptic reorganization in a diseased...