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Light-evoked deformations in rod photoreceptors, pigment epithelium and subretinal space revealed by prolonged and multilayered optoretinography
Phototransduction involves changes in concentration of ions and other solutes within photoreceptors and in subretinal space, which affect osmotic...
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Subretinal Fluid and Retinal Detachment
The neurosensory retina and the RPE are normally glued to each other by an interphotoreceptor-binding protein matrix without forming any adhesions....
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Naïve subretinal haemorrhage due to neovascular age-related macular degeneration. pneumatic displacement, subretinal air, and tissue plasminogen activator: subretinal vs intravitreal aflibercept-the native study
ObjectiveWe aimed to compare visual and anatomical outcome in subretinal aflibercept vs. intravitreal aflibercept in the context of Pars Plana...
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Effect of external subretinal fluid drainage on persistent subretinal fluid after scleral buckle surgery in macula-involving rhegmatogenous retinal detachment
This study aimed to analyze the duration and causes of persistent subretinal fluid (PSF) after scleral buckle (SB) surgery in patients with...
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Subretinal Pseudocysts: A Comprehensive Analysis of this Novel OCT Finding
IntroductionIn current clinical practice, several optical coherence tomography (OCT) biomarkers have been proposed for the assessment of severity and...
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Splenic monocytes drive pathogenic subretinal inflammation in age-related macular degeneration
Age-related macular degeneration (AMD) is invariably associated with the chronic accumulation of activated mononuclear phagocytes in the subretinal...
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iOCT-guided simulated subretinal injections: a comparison between manual and robot-assisted techniques in an ex-vivo porcine model
The purpose of this study is to compare robot-assisted and manual subretinal injections in terms of successful subretinal blistering, reflux...
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Subretinal peripapillary biopsy-proven sarcoidosis: a case report
BackgroundTo report a case of a subretinal, unilateral, peripapillary granuloma that was diagnosed as sarcoidosis by a 27-gauge pars plana vitrectomy...
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Characteristics of subretinal particles detected after pars plana vitrectomy for rhegmatogenous retinal detachment
BackgroundTo determine the incidence and characteristics of the multiple subretinal particles (SRPs) present after pars plana vitrectomy (PPV) for...
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Robot-assisted subretinal injection system: development and preliminary verification
BackgroundTo design and develop a surgical robot capable of assisting subretinal injection.
MethodsA remote center of motion (RCM) mechanical design...
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Surgical Approach with Pars Plana Vitrectomy for Subretinal Gene Therapy
Gene therapy is emerging as a treatment for inherited diseases including retinitis pigmentosa. Through surgery, specifically with pars plana...
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Subretinal transient hyporeflectivity in neovascular age-related macular degeneration and its response to a loading phase of aflibercept: PRECISE report 4
PurposeTo describe the prevalence of subretinal transient hyporeflectivity (STHR) in exudative neovascular age-related macular degeneration (nAMD)...
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A design and modeling perspective on photostimulation of the subretinal prosthesis with graphene-based photodiodes
The two leading causes of blindness in the developed world are age-related macular degeneration and retinitis pigmentosa. The photostimulation of...
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Subretinal/Submacular Haemorrhage
Haemorrhage under the neurosensory retina or the retinal pigment epithelium in the macula is a sight-threatening condition. It is a significant...
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Sharper vision, steady hands: can robots improve subretinal drug delivery? Systematic review
Subretinal injection (SI) is a novel drug delivery method, directly to retina for treatment of various eye disease. However, manual injection...
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Subretinal abscess: causative pathogens, clinical features and management
PurposeTo review the literature on endogenous subretinal abscess (SRA).
MethodsWe searched in the literature for the terms ‘subretinal abscess’,...
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Micromanipulator-Assisted Subretinal Transplantation of Human Photoreceptor Reporter Cell Suspensions into Mice
Retinopathies marked by photoreceptor cell loss are the main cause of visual impairment and blindness in industrialized societies. Photoreceptor...
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E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration
Activated microglia have been implicated in the pathogenesis of age-related macular degeneration (AMD), diabetic retinopathy, and other...
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Ocular Injection Techniques for Retinitis Pigmentosa: Intravitreal, Subretinal, and Suprachoroidal
Ocular gene therapyGene therapies represents an emerging and promising therapeutic approach for the treatment of several of the inherited retinal...