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A comparison of physiologically equivalent temperature based on model simulation and site observation data for Iran
Climate change will have a great impact on thermal bioclimate conditions and thermal perceptions, and statistical downscaling methods may introduce...
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Investigating beach tourism climate of Mazandaran Province emphasizing the sustainable development approach using beach climate index (BCI) and physiologically equivalent temperature (PET)
The present study aimed to review the spatiotemporal distribution of tourism climate conditions in Mazandaran province using two indicators, i.e.,...
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Characteristic of bioclimatic conditions in Poland based on Physiologically Equivalent Temperature
The aim of the study was to characterise bioclimatic conditions in Poland in the times of progressing warming. This type of research permits the...
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A Luciferase Imaging-Based Assay for Studying Temperature Compensation of the Circadian Clock
The pace of circadian rhythms remains relatively unchanged across a physiologically relevant range of temperatures, a phenomenon known as temperature...
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SubQ-Sim: A Subcutaneous Physiologically Based Biopharmaceutics Model. Part 1: The Injection and System Parameters
PurposeTo construct a detailed mechanistic and physiologically based biopharmaceutics model capable of predicting 1) device-formulation-tissue...
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Single-molecule magnetic tweezers to probe the equilibrium dynamics of individual proteins at physiologically relevant forces and timescales
The reversible unfolding and refolding of proteins is a regulatory mechanism of tissue elasticity and signalling used by cells to sense and adapt to...
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Increasing Temperature Risk and Community Resilience: Urban Aspects
Indonesia’s urban density has increased in the past 10 years. This paper discusses land use and cover changes (LULC) from 2019 to 2009 which led to...
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Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies
The human airways are complex structures with important interactions between cells, extracellular matrix (ECM) proteins and the biomechanical...
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Physiologically Based Modelling Framework for Prediction of Pulmonary Pharmacokinetics of Antimicrobial Target Site Concentrations
Background and ObjectivesPrediction of antimicrobial target-site pharmacokinetics is of relevance to optimize treatment with antimicrobial agents. A...
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Physiological equivalent temperature (PET) index and respiratory hospital admissions in Ahvaz, southwest of Iran
Although Ahvaz is considered as one of the warmest cities around the world, few epidemiological studies have been conducted on the adverse effects of...
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From hazard to risk prioritization: a case study to predict drug-induced cholestasis using physiologically based kinetic modeling
Cholestasis is characterized by hepatic accumulation of bile acids. Clinical manifestation of cholestasis only occurs in a small proportion of...
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Characterization, cellular uptake in Caco-2 cells and physiologically based pharmacokinetic modeling of baicalin-loaded solid lipid nanoparticles
BackgroundBaicalin is a natural compound having intriguing and useful pharmacological properties that may be used alone or in conjunction with other...
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Thermal indices for human biometeorology based on Python
Thermal indices, such as Predicted Mean Vote, Outdoor Standard Effective Temperature, Physiologically Equivalent Temperature, and Universal Thermal...
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Generation of Three-Dimensional Retinal Tissue with Physiologically Competent, Light-Sensitive Photoreceptors from Human-Induced Pluripotent Stem Cells
Human retinal organoids are three-dimensional tissue systems derived from human pluripotent stem cells (hPSCs) that recreate aspects of the...
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Physiologically Based Biopharmaceutics Model for Selumetinib Food Effect Investigation and Capsule Dissolution Safe Space – Part I: Adults
ObjectiveA physiologically based biopharmaceutics model (PBBM) was developed to mechanistically investigate the effect of formulation and food on...
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Long-term survival, temperature, and torpor patterns
Mammalian and avian torpor is highly effective in reducing energy expenditure. However, the extent of energy savings achieved and thus long-term...
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Correlated color temperature is not a suitable proxy for the biological potency of light
Using a simulation based on a real, five-channel tunable LED lighting system, we show that Correlated Color Temperature (CCT) is not a reasonable...
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Monitoring Real-Time Temperature Dynamics of a Short RNA Hairpin Using Förster Resonance Energy Transfer and Circular Dichroism
RNA molecules play crucial roles in gene expression regulation and cellular signaling, and these functions are governed by the formation of RNA...
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Differences in transcription regulation of diurnal metabolic support to physiologically contrasting seasonal life-history states in migratory songbirds
We hypothesized that there were diurnal differences in metabolism, with major transcriptional changes occurring early during the day and/or night...
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Comparison of fluid dynamics changes due to physical activity in 3D printed patient specific coronary phantoms with the Windkessel equivalent model of coronary flow
Background3D printing (3DP) used to replicate the geometry of normal and abnormal vascular pathologies has been demonstrated in many publications;...
