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Nuclear-import receptors as gatekeepers of pathological phase transitions in ALS/FTD
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders on a disease spectrum that are...
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Yeast 26S proteasome nuclear import is coupled to nucleus-specific degradation of the karyopherin adaptor protein Sts1
In eukaryotes, the ubiquitin–proteasome system is an essential pathway for protein degradation and cellular homeostasis. 26S proteasomes concentrate...
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Monitoring HIV-1 Nuclear Import Kinetics Using a Chemically Induced Nuclear Pore Blockade Assay
To integrate with host chromatin and establish a productive infection, HIV-1 must translocate the viral Ribonucleoprotein (RNP) complex through the...
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Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN
The majority of lncRNAs and a small fraction of mRNAs localize in the cell nucleus to exert their functions. A SIRLOIN RNA motif was previously...
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Imaging HIV-1 Nuclear Import, Uncoating, and Proviral Transcription
Live-cell imagingLive cell imaging has become a powerful tool for dissecting the behavior of viral complexes during HIV-1 infection with high...
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Metals at the nexus: renewable vs. nuclear energy systems, metal import requirements, and energy security in the European Union
This study examines the compatibility of the EU’s current 2050 clean energy transition plan, aiming to increase the share of renewable power...
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Nuclear import of Mas-related G protein-coupled receptor member D induces pathological cardiac remodeling
Alamandine (Ala), a ligand of Mas-related G protein-coupled receptor, member D (MrgD), alleviates angiotensin II (AngII)-induced cardiac hypertrophy....
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The HIV-1 capsid core is an opportunistic nuclear import receptor
The movement of viruses and other large macromolecular cargo through nuclear pore complexes (NPCs) is poorly understood. The human immunodeficiency...
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Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy
BackgroundCytoplasmic mislocalization and aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of the amyotrophic lateral sclerosis and...
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Mechanical control of nuclear import by Importin-7 is regulated by its dominant cargo YAP
Mechanical forces regulate multiple essential pathways in the cell. The nuclear translocation of mechanoresponsive transcriptional regulators is an...
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Rescue of mitochondrial import failure by intercellular organellar transfer
Mitochondria are the powerhouses of eukaryotic cells, composed mostly of nuclear-encoded proteins imported from the cytosol. Thus, problems with the...
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AKIRIN2 controls the nuclear import of proteasomes in vertebrates
Protein expression and turnover are controlled through a complex interplay of transcriptional, post-transcriptional and post-translational mechanisms...
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The nuclear import receptor Kapβ2 modifies neurotoxicity mediated by poly(GR) in C9orf72-linked ALS/FTD
Expanded intronic G 4 C 2 repeats in the C9ORF72 gene cause amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). These intronic...
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Differential nuclear import sets the timing of protein access to the embryonic genome
The development of a fertilized egg to an embryo requires the proper temporal control of gene expression. During cell differentiation, timing is...
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Detection of CPSF6 in Biomolecular Condensates as a Reporter of HIV-1 Nuclear Import
The initial stages of HIV-1 infection involve the transport of the viral core into the nuclear compartment. The presence of the HIV-1 core in the...
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Nuclear import of PTPN18 inhibits breast cancer metastasis mediated by MVP and importin β2
Distant metastasis is the primary cause of breast cancer-associated death. The existing information, such as the precise molecular mechanisms and...
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Chaperone proteins and peroxisomal protein import
Peroxisomes are ubiquitous organelles present in most eukaryotic cells. Their role in cellular metabolism is diverse among species. An array of genes...
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The nuclear entry of the aryl hydrocarbon receptor (AHR) relies on the first nuclear localization signal and can be negatively regulated through IMPα/β specific inhibitors
The human aryl hydrocarbon receptor (AHR) undergoes continuous shuttling between nucleus and cytoplasm. Binding to exogenous or endogenous ligands...
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Hormone-Inducible Transport Reporter Assay to Study Nuclear Import Defects in Neurodegenerative Diseases
In the recent years, defective nuclear import has emerged as an important pathomechanism of neurodegenerative diseases, particularly in amyotrophic...
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Import Component of the Russian Rare Metal Market
Abstract —The dependence of the Russian industry on the import of rare metals is considered. The volume of imports and their geographical structure,...
