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1. KLF4 transcription factor in tumorigenesis

   Krüppel-like transcriptional factor is important in maintaining cellular functions. Deletion of Krüppel-like transcriptional factor usually causes...

   Zhihong He, Jie He, Ke** **e in Cell Death Discovery

   Article Open access 08 April 2023
   

2. KLF4 facilitates chromatin accessibility remodeling in porcine early embryos

   Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early embryos. Current studies have illustrated...

   Wei Zhu, Guowei Bu, ... Yi-Liang Miao in Science China Life Sciences

   Article 07 September 2023

3. KLF4 Induces Colorectal Cancer by Promoting EMT via STAT3 Activation

   Objective

   Krüppel-like factor 4 (KLF4) has been demonstrated to exert a pro-carcinogenic effect in solid tissues. However, the precise biological...

   Lebin Yuan, Yanqiu Meng, Jiajia **ang in Digestive Diseases and Sciences

   Article 30 May 2024
   

4. KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro

   Objective

   Hepatic stellate cells (HSCs) play a crucial role in liver fibrosis. Early-stage liver fibrosis is reversible and intimately associated with...

   **ng-yu Yang, Zhe Chen, ... Hai Zheng in Current Medical Science

   Article 24 May 2024

5. Role of lipid metabolism gene KLF4 in osteoarthritis

   Introduction

   Osteoarthritis (OA) is a common degenerative disease of joints, which can appear in almost any joint of the body. Therefore, the...

   Kaibo Hu, Yuan Shu, ... Liang Hao in Clinical Rheumatology

   Article 23 August 2023
   

6. Divergent Roles of KLF4 During Primordial Germ Cell Fate Induction from Human Embryonic Stem Cells

   As a core transcriptional factor regulating pluripotency, Krüppel-like factor 4 (KLF4) has gained much attention in the field of stem cells during...

   Fang Fang, Zili Li, ... **ao Wang in Reproductive Sciences

   Article 26 October 2023
   

7. Effect of overexpression of KLF4 on the growth and development of hair follicles in mice

   Hair follicle growth is cyclical, and hair cycle dysfunction can lead to hair follicle-related disorders, including alopecia and hirsutism. The...

   Hongyu Han, Hong Qin, ... Quanhai Pang in Development Genes and Evolution

   Article 10 August 2023
   

8. EphA2 promotes the transcription of KLF4 to facilitate stemness in oral squamous cell carcinoma

   Ephrin receptor A2 (EphA2), a member of the Ephrin receptor family, is closely related to the progression of oral squamous cell carcinoma (OSCC)....

   Junqiang Bai, Yang Chen, ... Zhe Shao in Cellular and Molecular Life Sciences

   Article Open access 25 June 2024
   

9. KLF4 overexpression facilitates proliferation and represses apoptosis of granulosa cells in polycystic ovary syndrome

   Background

   Polycystic ovary syndrome (PCOS) is defined as a complex endocrinopathy greatly affecting reproductive-aged women. Krüppel-like factors...

   Hui Miao, Congxiu Miao, ... **g Han in Molecular & Cellular Toxicology

   Article 27 June 2023
   

10. KLF4 regulates skeletal muscle development and regeneration by directly targeting P57 and Myomixer

    Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes...

    Shufang Cai, **aoyu Wang, ... Delin Mo in Cell Death & Disease

    Article Open access 18 September 2023
    

11. FAM3A reshapes VSMC fate specification in abdominal aortic aneurysm by regulating KLF4 ubiquitination

    Reprogramming of vascular smooth muscle cell (VSMC) differentiation plays an essential role in abdominal aortic aneurysm (AAA). However, the...

    Chuxiang Lei, Haoxuan Kan, ... Yuehong Zheng in Nature Communications

    Article Open access 02 September 2023
    

12. Circ_0020256 induces fibroblast activation to drive cholangiocarcinoma development via recruitment of EIF4A3 protein to stabilize KLF4 mRNA

    Cancer-associated fibroblasts (CAFs) are a kind of stromal cells in the cholangiocarcinoma (CCA) microenvironment, playing crucial roles in cancer...

    Zongyan Li, Zuxiao Chen, ... Dawei Zhang in Cell Death Discovery

    Article Open access 13 May 2023
    

13. KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells

    Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays...

    **nhua Zhang, Bin Zheng, ... **kun Wen in Communications Biology

    Article Open access 05 December 2022
    

14. Agmatine-IRF2BP2 interaction induces M2 phenotype of microglia by increasing IRF2-KLF4 signaling

    Background

    Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both...

    Jiwon Kim, A Young Sim, ... Jong Eun Lee in Inflammation Research

    Article 14 June 2023
    

15. Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia

    TAL1 is one of the most frequently dysregulated genes in T-ALL and is overexpressed in about 50% of T-ALL cases. One of the molecular mechanisms of TAL1...

    Mina Noura, Hidemasa Matsuo, ... Fumihiko Hayakawa in Oncogene

    Article 15 December 2023
    

16. The critical role of KLF4 in regulating the activation of A1/A2 reactive astrocytes following ischemic stroke

    Background

    We have previously demonstrated that the expression of kruppel-like transcription factor-4 (KLF-4) is upregulated in astrocytes following...

    Cong Wang, Longxuan Li in Journal of Neuroinflammation

    Article Open access 23 February 2023
    

17. CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function

    Background

    Pulmonary fibrosis is a growing clinical problem that develops as a result of abnormal wound healing, leading to breathlessness, pulmonary...

    Wenqing Sun, Siyun Zhou, ... Chunhui Ni in Cellular & Molecular Biology Letters

    Article Open access 18 December 2023
    

18. CUL4B orchestrates mesenchymal stem cell commitment by epigenetically repressing KLF4 and C/EBPδ

    Dysregulated lineage commitment of mesenchymal stem cells (MSCs) contributes to impaired bone formation and an imbalance between adipogenesis and...

    Ruiqi Yu, Hong Han, ... Yaoqin Gong in Bone Research

    Article Open access 02 June 2023
    

19. N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells

    Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle...

    Kang Kang, Chuannan Sun, ... Deming Gou in Cellular and Molecular Life Sciences

    Article Open access 12 June 2024
    

20. Cardiac Fibroblast Activation Induced by Oxygen–Glucose Deprivation Depends on the HIF-1α/miR-212-5p/KLF4 Pathway

    It is widely accepted that miRNAs play an important role in the pathogenesis of myocardial fibrosis. This study aimed to identify a new pathway of...

    Hongbing Li, Chenxing Li, ... Tao Chen in Journal of Cardiovascular Translational Research

    Article 07 June 2023