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Gap Junctions in Ctenophora
Gap junction proteins form specialized intercellular communication channels, including electrical synapses, that regulate cellular metabolism and...
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DNA Methylation in Ctenophores
Epigenomic regulation and dynamic DNA methylation, in particular, are widespread mechanisms orchestrating the genome operation across time and...
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A Dye Uptake Assay to Measure Large-Pore Channel Activity in Trypanosoma cruzi
Large-pore channels allow the exchange of ions and molecules between the intra- and extracellular compartments. These channels are structures formed...
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In silico analyses suggest the cardiac ganglion of the lobster, Homarus americanus, contains a diverse array of putative innexin/innexin-like proteins, including both known and novel members of this protein family
Gap junctions are physical channels that connect adjacent cells, permitting the flow of small molecules/ions between the cytoplasms of the coupled...
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Gap Junctions and Electric Synapses
Signal transmission between neurons is mediated in multiple distinct ways. In the adult brain, transmission via neurotransmitters (chemical synapsis)...
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Brief History of Placozoa
Placozoans are morphologically the simplest free-living animals. They represent a unique window of opportunities to understand both the origin of the...
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Understanding neural circuit function through synaptic engineering
Synapses are a key component of neural circuits, facilitating rapid and specific signalling between neurons. Synaptic engineering — the synthetic...
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Brief History of Ctenophora
Ctenophores are the descendants of the earliest surviving lineage of ancestral metazoans, predating the branch leading to sponges (Ctenophore-first...
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The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic muscle contraction in C. elegans
FMRFamides are evolutionarily conserved neuropeptides that play critical roles in behavior, energy balance, and reproduction. Here, we show that...
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Neurodegeneration and Neuroinflammation: The Role of Pannexin 1
Abstract—Pannexins are capable of forming in the cell membrane anion channels with relatively low conductivity, as well as channels with high...
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Locomotion modulates olfactory learning through proprioception in C. elegans
Locomotor activities can enhance learning, but the underlying circuit and synaptic mechanisms are largely unknown. Here we show that locomotion...
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The structures and gating mechanism of human calcium homeostasis modulator 2
Calcium homeostasis modulators (CALHMs) are voltage-gated, Ca 2+ -inhibited nonselective ion channels that act as major ATP release channels, and have...
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Glial Chloride Channels in the Function of the Nervous System Across Species
In the nervous system, the concentration of Cl− in neurons that express GABA receptors plays a key role in establishing whether these neurons are...
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Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell–Cell Channels
Gap junctions, pivotal intercellular conduits, serve as communication channels between adjacent cells, playing a critical role in modulating membrane...
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Neuronal gene expression in two generations of the marine parasitic worm, Cryptocotyle lingua
Trematodes, or flukes, undergo intricate anatomical and behavioral transformations during their life cycle, yet the functional changes in their...
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Analysis of Molecular Circuitry Integrated to Lethargus State of Caenorhabditis elegans: A Review
Sleep is a quintessential phenomenon of our nervous system. In spite of enduring research, the complexity of brain makes it more challenging to...
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Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms
Pannexins are single-membrane large-pore channels that release ions and ATP upon activation. Three isoforms of pannexins 1, 2, and 3, perform diverse...
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Analysis of the C. elegans Germline Stem Cell Pool
The Caenorhabditis elegans germline is an excellent model for studying the genetic and molecular regulation of stem cell self-renewal and progression...