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The Role of Interleukin (IL)-6/IL-6 Receptor Axis in Cancer
As a pleiotropic cytokine, interleukin (IL)-6 plays a key role in mediating the host’s immune defense. Multiple cell types are involved in IL-6...
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Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What Have We Learned?
The use of different pathways in the treatment of rheumatoid arthritis has led to a significant decrease in the number of treatment-resistant...
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Resolvin D1 Inhibits IL-6-Induced Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Targeting IL-6/STAT3 Signaling
Colorectal cancer (CRC) has emerged as a prevalent malignancy worldwide, exhibiting the high morbidity and mortality rates. Resolvin D1 (RvD1) can...
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Taming the cytokine storm: small molecule inhibitors targeting IL-6/IL-6α receptor
Given the increasing effectiveness of immune-based therapies, management of their associated toxicities is of utmost importance. Cytokine release...
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CRP, IL-1α, IL-1β, and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study
Epidemiological studies have reported a positive association between chronic inflammation and cancer risk. However, the causal association between...
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PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection
BackgroundIn the diagnosis of bloodstream infection (BSI), various inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT),...
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IL-6 prevents Th2 cell polarization by promoting SOCS3-dependent suppression of IL-2 signaling
Defective interleukin-6 (IL-6) signaling has been associated with Th2 bias and elevated IgE levels. However, the underlying mechanism by which IL-6...
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Association of IL-4 (− 590 C/T) and IL-6 (− 174 G/C) gene polymorphism in South Indian CKD patients
AimThe present study was undertaken to examine the role of IL-4 (− 590 C/T) (rs2243250) and IL-6 (− 174G/C) (rs1800795) polymorphism and the serum...
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The Role of IL-6 in Neurodegenerative Disorders
“Neurodegenerative disorder” is an umbrella term for a group of fatal progressive neurological illnesses characterized by neuronal loss and...
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Expression and significance of IL-6 and IL-8 in canine mammary gland tumors
Mammary gland tumors are the most common malignant diseases which seriously threaten the health of women and female dogs. There is a lack of an...
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PCR-positive meningococcal CSF infection without pleocytosis but high IL-6 and IL-8
BackgroundMeningococcal meningitis is still a severe disease causing high mortality and morbidity rates. Early diagnosis is crucial to ensure prompt...
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Launaea fragilis extract attenuated arthritis in rats through modulation of IL-1β, TNF-α, IL-6, NF-κB, COX-2, IL-4, and IL-10
Launaea fragilis (Asso) Pau is a Cholistan desert medicinal plant. Launaea species are used as traditional remedies against various inflammatory...
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Targeting IL-6 trans-signalling: past, present and future prospects
Interleukin-6 (IL-6) is a key immunomodulatory cytokine that affects the pathogenesis of diverse diseases, including autoimmune diseases, chronic...
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Intratumoral Delivery of Genetically Engineered Anti-IL-6 Trans-signaling Therapeutics
Interleukin-6 (IL-6) is a highly pro-inflammatory cytokine involved in the etiopathology of several inflammatory diseases and cancer. As so, the...
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Assessment of selected interleukins (IL-6, IL-17A, IL-18, IL-23) and chemokines (RANTES, IP-10) in children with acute and chronic urticaria
BackgroundUrticarial lesions develop as a result of the activation of mast cells which, through the release of mediators, influence the formation of...
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Farnesoid X receptor promotes non-small cell lung cancer metastasis by activating Jak2/STAT3 signaling via transactivation of IL-6ST and IL-6 genes
Metastasis accounts for the majority of cases of cancer recurrence and death in patients with advanced non-small cell lung cancer (NSCLC). Farnesoid...
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TNF-α, IL-1B and IL-6 affect the differentiation ability of dental pulp stem cells
BackgroundThis in vitro study examined the effect of the inflammatory cytokines (tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6) on...
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ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells
Colorectal cancer (CRC) is a worldwide health concern. Chronic inflammation is a risk factor for CRC, and interleukin-6 (IL-6) plays a pivotal role...
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Serum concentrations of proinflammatory biomarker interleukin-6 (IL-6) as a predictor of postoperative complications after elective colorectal surgery
BackgroundThe aim of this prospective study was to evaluate the role of serum IL-6 as a potential predictive biomarker of postoperative complications...
