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Frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early...
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Frontotemporal lobar degeneration in the “Annual of the Pathological Autopsy Cases in Japan”
BackgroundGood accuracy for the clinical diagnosis of frontotemporal lobar degeneration (FTLD) by specialists in an early onset dementia clinic has...
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Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration
There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies....
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Presymptomatic and early pathological features of MAPT-associated frontotemporal lobar degeneration
Early pathological features of frontotemporal lobar degeneration (FTLD) due to MAPT pathogenic variants (FTLD-MAPT) are understudied, since...
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TAF15 amyloid filaments in frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) causes frontotemporal dementia (FTD), the most common form of dementia after Alzheimer’s disease, and is...
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Increase in wasteosomes (corpora amylacea) in frontotemporal lobar degeneration with specific detection of tau, TDP-43 and FUS pathology
Wasteosomes (or corpora amylacea) are polyglucosan bodies that appear in the human brain with aging and in some neurodegenerative diseases, and have...
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Association of cortical and subcortical microstructure with disease severity: impact on cognitive decline and language impairments in frontotemporal lobar degeneration
BackgroundCortical and subcortical microstructural modifications are critical to understanding the pathogenic changes in frontotemporal lobar...
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Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales
Self-report scales are widely used in cognitive neuroscience and psychology. However, they rest on the central assumption that respondents engage...
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Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) is a common cause of young onset dementia and is characterised by focal neuropathology. The reasons for the...
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Brain DNA methylomic analysis of frontotemporal lobar degeneration reveals OTUD4 in shared dysregulated signatures across pathological subtypes
Frontotemporal lobar degeneration (FTLD) is an umbrella term describing the neuropathology of a clinically, genetically and pathologically...
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Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
Frontotemporal lobar degeneration with MAPT pathogenic variants (FTLD-MAPT) has heterogeneous tau pathological inclusions postmortem, consisting of...
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The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration
There is a pressing need to accelerate therapeutic strategies against the syndromes caused by frontotemporal lobar degeneration, including...
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Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
Impaired proteostasis is associated with normal aging and is accelerated in neurodegeneration. This impairment may lead to the accumulation of...
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Resting state functional brain networks associated with emotion processing in frontotemporal lobar degeneration
This study investigated the relationship between emotion processing and resting-state functional connectivity (rs-FC) of the brain networks in...
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Elecsys Cerebrospinal Fluid Assays Accurately Distinguish Alzheimer’s Disease from Frontotemporal Lobar Degeneration
BackgroundAlzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) are heterogeneous in their clinical presentation and underlying...
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Plasma biomarkers increase diagnostic confidence in patients with Alzheimer’s disease or frontotemporal lobar degeneration
BackgroundThe recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the future of...
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Frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43): its journey of more than 100 years
Frontotemporal lobar degeneration (FTLD) with TDP-43-immunoreactive inclusions (FTLD–TDP) is a neurodegenerative disease associated with clinical,...
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Classification accuracy of blood-based and neurophysiological markers in the differential diagnosis of Alzheimer’s disease and frontotemporal lobar degeneration
BackgroundIn the last decade, non-invasive blood-based and neurophysiological biomarkers have shown great potential for the discrimination of several...
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Measuring social cognition in frontotemporal lobar degeneration: a clinical approach
Alterations in social cognition, a broad term indicating our ability to understand others and adapt our behavior accordingly, have been the focus of...
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Signature laminar distributions of pathology in frontotemporal lobar degeneration
Frontotemporal lobar degeneration (FTLD) with either tau (FTLD-tau) or TDP-43 (FTLD-TDP) inclusions are distinct proteinopathies that frequently...
