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Coculture with macrophages alters ferroptosis susceptibility of triple-negative cancer cells
Various treatment options, such as molecular targeted drugs and immune checkpoint blockades, are available for patients with cancer. However, some...
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A Coculture System for Modeling Intestinal Epithelial-Fibroblast Crosstalk
Epithelial organoid monoculture is a powerful tool to model stem cell dynamics in vitro. However, extensive efforts have recently revealed various...
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Advanced Organotypic In Vitro Model Systems for Host–Microbial Coculture
In vitro model systems have been advanced to recapitulate important physiological features of the target organ in vivo more closely than the...
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Soil bacterial community composition in rice-turtle coculture systems with different planting years
The rice-turtle coculture system is the most special rice-fish integrated farming system. In this study, we selected four paddy fields, including a...
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Enhanced upgrading of lignocellulosic substrates by coculture of Saccharomyces cerevisiae and Acinetobacter baylyi ADP1
BackgroundLignocellulosic biomass as feedstock has a huge potential for biochemical production. Still, efficient utilization of hydrolysates derived...
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Coculture and Immobilization of Cellulolytic Bacteria for Enhanced Glucose Isomerase Production from Wheat Straw
Coculture and whole-cell immobilization have myriad industrial applications for enhancing enzyme production. Using pretreated wheat straw as the sole...
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MSC and HSPC Coculture: Mimicking Ex Vivo Bone Marrow Niche
Mesenchymal stromal cells (MSCs) are the crucial component of the hematopoietic stem and progenitor cell (HSPC) niche in the bone marrow. Therefore,...
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Light-independent anaerobic microbial oxidation of manganese driven by an electrosyntrophic coculture
Anaerobic microbial manganese oxidation (AMMO) has been considered an ancient biological metabolism for Mn element cycling on Archaean Earth before...
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Coculture of bacterial levans and evaluation of its anti-cancer activity against hepatocellular carcinoma cell lines
This research represents a novel study to assess how coculture affects levan yield, structure, bioactivities, and molecular weight. Among the 16...
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Enhanced production of 3-phenyllactic acid from novel non-axenic coculture: adaptive evolution and statistical fermentation studies
This research pivots around screening of idoneous lactic acid bacteria (LAB) from cow milk and subjecting them to adaptive evolution experiments to...
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Optimizing tumor-associated antigen-stimulated autologous dendritic cell and cytokine-induced killer cell coculture to enhance cytotoxicity for cancer immunotherapy in manufacturing
BackgroundDendritic Cell Cytokine-induced killer cell (DC-CIK) coculture treatment in cancer immunotherapy has been shown to be effective. However,...
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Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model
BackgroundRecently, natural killer (NK) cells emerged as a treatment option for various solid tumors. However, the immunosuppressive tumor immune...
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A rapid screening platform to coculture bacteria within tumor spheroids
The prevalence of tumor-colonizing bacteria along with advances in synthetic biology are leading to a new generation of living microbial cancer...
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Recent Progress in Microbial Biosynthesis by Coculture Engineering
AbstractWith the development of metabolic engineering and synthetic biology, a large number of industrially important products has been developed...
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Application of a novel biological-nanoparticle pretreatment to Oscillatoria acuminata biomass and coculture dark fermentation for improving hydrogen production
BackgroundEnergy is the basis and assurance for a world's stable development; however, as traditional non-renewable energy sources deplete, the...
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Human Hepatic Spheroid Coculture Model for the Assessment of Drug-Induced Liver Injury
Accurate evaluation of potential drug risks such as drug-induced liver injury (DILI) continues to be a challenge faced by pharmaceutical industry and...
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Monoculture and Coculture of Sesuvium portulacastrum and Sulla carnosa Under Saline and Non-Saline Conditions: Plant Vigour and Soil Phytodesalination
The aim of the present work was to study the possibility of coculture of the two halophytes Sesuvium portulacastrum – Sulla carnosa under saline and...
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Quantitative Determination of Antibacterial Activity During Bacterial Coculture
Antibacterial activity assays are an important tool in the assessment of the ability of one bacterium to kill or inhibit the growth of another, for...
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The deposition of lanthanum carbonate may activate macrophages to induce gastrointestinal mucosal injury in patients with chronic kidney disease: an in vitro caco-2/THP-1 macrophage coculture model study
The aim of this study was to investigate the effect and possible underlying mechanism of La 2 (CO 3 ) 3 deposition on GI mucosal inflammation. Our results...
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Establishment of a mechanism-based in vitro coculture assay for evaluating the efficacy of immune checkpoint inhibitors
Cancer immunotherapy, which blocks immune checkpoint molecules, is an effective therapeutic strategy for human cancer patients through restoration of...
